Musculoskeletal Injury Prevention, Treatment, and rehabilitation

This capability spans evidence-based preventive strategies, point-of-injury orthopaedics, rapid stabilization and fixation, biologic and device-enabled tissue repair, and progressive functional rehabilitation. It addresses acute and chronic musculoskeletal conditions common in combat and prolonged-field environments to restore function and maintain force readiness.

Technical Challenges

  • High incidence of blast- and impact-related fractures and polytrauma with limited forward surgical capability

  • Delayed evacuation and prolonged field care increase risk of infection, compartment syndrome, and poor healing

  • Complex soft-tissue and nerve injuries requiring integrated biologic and mechanical repair strategies

  • Heterogeneous rehabilitation environments and limited access to sustained, high-fidelity therapy in austere settings

  • Diagnostic gaps for early detection of stress injuries, nonunion, and impaired healing under operational stressors

Emerging Opportunities

  • Lightweight, ruggedized stabilization and fixation devices suitable for far-forward use

  • Biologics and scaffolds that accelerate bone and soft-tissue regeneration with minimal cold-chain needs

  • Portable diagnostics and biomarkers to monitor healing, infection, and inflammatory states in-field

  • Adaptive rehabilitation platforms (remote/tele-rehab, wearable sensors, robotics) that function in distributed care

  • Validated prevention programs and wearable risk-assessment tools that integrate load management and human performance data

Current and Emerging Technologies in Musculoskeletal Injury Prevention, Treatment, and rehabilitation

Tactical stabilization devices

Lightweight external fixation, modular splints, and deployable orthoses designed for rapid application in austere environments to protect fractures and soft-tissue injuries.

Biologics and regenerative scaffolds

Bone graft substitutes, cell-based therapies, and synthetic scaffolds that promote osteogenesis and soft-tissue repair while resisting infection and reducing time-to-union.

Point-of-care diagnostics and biomarkers

Portable imaging adjuncts, serum and wound biomarkers, and biosensors to detect infection, inflammation, compartment pressures, and early nonunion risk.

Wearables and load-monitoring

Inertial sensors, GPS-integrated devices, and force-monitoring insoles for injury risk prediction, activity dosing, and remote monitoring during training and deployment.

Tele-rehabilitation and robotics

Telehealth platforms, virtual PT, exoskeletons, and portable robotic assist devices that extend specialist-led rehabilitation into distributed and prolonged-care settings.

Antimicrobial strategies for musculoskeletal wounds

Local antibiotic delivery systems, anti-biofilm coatings, and AMR-aware wound care protocols to prevent infection and preserve implant and tissue viability.

Importance to Military Medicine

Preserve force readiness

Rapid prevention, stabilization, and rehab reduce downtime and recurrent injury, maintaining deployable strength and unit readiness.

Enable prolonged and austere care

Technologies tailored for forward environments support life- and limb-saving interventions when evacuation is delayed.

Mitigate long-term disability

Integrated approaches reduce chronic pain, nonunion, and loss of function that contribute to medical discharge and lifetime care costs.

Address complex combat injury patterns

From blast injuries to overuse stress fractures, military-specific solutions must integrate trauma, infection control, and performance optimization.

Alignment with the MTEC Mission

Advances in musculoskeletal care directly accelerate field-to-factory translation of medical technologies, aligning with MTEC’s mission to deliver deployable solutions faster.

Cross-disciplinary projects—combining regenerative medicine, diagnostics, wearables, and telehealth—map to MTEC’s broad portfolio and consortium model.

Solutions that reduce evacuation needs and enable prolonged care support DoD priorities for distributed medical readiness and operational resilience.

Dual-use potential for civilian trauma, orthopedics, and sports medicine amplifies MTEC’s objective of benefiting both Warfighters and the public.

Dual-Use (Military + Civilian) Applications

Forward stabilization and early orthopedic interventions in combat zones and disaster response.

Remote monitoring and tele-rehab for prolonged field care, garrison recovery, and austere medical facilities.

Civilian trauma centers, sports medicine, and orthopedic surgery benefiting from ruggedized devices, biologics, and scalable rehab platforms.

Explore MTEC Members with Musculoskeletal Injury Prevention, Treatment, and rehabilitation Capabilities

MTEC members bring multidisciplinary strengths—orthopaedic surgery, materials science, regenerative medicine, wearable sensing, and telehealth implementation—to accelerate validated solutions.

Members’ partnerships across academia, industry, and military clinical sites enable rigorous clinical trials, manufacturing scale-up, and rapid operational evaluation.

Explore member profiles to identify collaborators with expertise in tactical orthopaedics, biologic therapies, diagnostics, and remote rehabilitation to co-develop solutions for Warfighters and civilians alike.

103 Members with Musculoskeletal Injury Prevention, Treatment, and rehabilitation capabilities.

Member
SIMETRI

SIMETRI is a woman-and-minority owned small business based in Winter Park, Florida, specializing in modeling, simulation, and training technologies. Founded in 2009, the company focuses on delivering innovative products and services that enhance the human experience and improve client outcomes through advanced training and program management analysis.

Member
Advanced Regenerative Manufacturing Institute (ARMI)

The Advanced Regenerative Manufacturing Institute (ARMI) is a member-based, nonprofit organization dedicated to advancing the bioeconomy of the United States. Its mission encompasses enhancing manufacturing, healthcare, and education and workforce development, aiming to create a scalable and effective manufacturing ecosystem for engineered cells, tissues, and organs.

Member
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Member
NervGen Pharma Corp

NervGen Pharma Corp is a clinical-stage biotech company focused on developing innovative treatments to enable nervous system repair in cases of traumatic injury and disease. Their lead drug candidate, NVG-291, is currently being evaluated in a Phase 1b/2a clinical trial for spinal cord injury, with additional preclinical evaluations for conditions such as ischemic stroke and amyotrophic lateral sclerosis (ALS). The company is also advancing a new development candidate, NVG-300, in preclinical studies.

Member
MediCarbone

MediCarbone is an Arizona-based orthopedic medical device startup founded in 2019, focused on revolutionizing bone fracture repair through minimally invasive, customized intramedullary nailing technology. The company utilizes patented carbon-fiber-reinforced polymer applications and AI technology to enhance patient outcomes in orthopedic treatments.

Member
Maverick Labs, Inc.

Maverick Labs is a U.S.-based biotechnology and materials science company specializing in advanced protein design, synthetic biology, and microbial engineering. The company operates through three tightly integrated subsidiaries—Maverick Metals, Maverick Energy, and the Maverick Bio-Gene Therapy Translational Unit—each of which applies a shared technological foundation to tackle critical challenges across national defense, energy independence, and strategic material access. Together, they develop scalable, field-ready solutions that reinforce the United States’ industrial resilience and military readiness through biotechnology-driven innovation.

Member
GreenLifeTech

GreenLifeTech has developed a safe, non-chemical means of removing oxygen from within a closed container operated at atmospheric pressure (no vacuum). This inert environment allows for the extending the shelf life of perishable material. Initially, the focus was on fresh produce which can have its shelf life extended by up to 3 - 5x, thereby reducing food waste and promoting healthier living. An EPA SBIR phase II contract has already been awarded for implementation of the technology in consumer refrigerators. In addition, the technology is applicable to preserving transfusion blood. NIH and US Army studies have already shown that storing blood in an anaerobic environment improves the quality and extends the shelf life of blood. The GreenLifeTech now makes this cost effective and applicable in the field.

Member
American Burn Association (ABA)

The American Burn Association (ABA) is a multidisciplinary organization dedicated to improving the lives of those affected by burn injury. With over 3,000 members worldwide, ABA focuses on promoting and supporting burn-related care, prevention, education, and research. The association brings together professionals from various disciplines to advance quality care, advocate for prevention, provide educational resources, and foster research in the field of burn injuries. ABA is also recognized for its leadership in advocacy, professional development, and the establishment of best practices and guidelines for burn care. The ABA regularly hosts conferences, develops clinical guidelines, and partners with organizations to raise awareness and improve outcomes for burn survivors.

Member
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

Member
SERDA Therapeutics

SERDA Therapeutics is a clinical stage biopharmaceutical company focused on developing innovative solutions for wound care, particularly in the treatment of burn injuries and chronic ulcers. The company aims to provide fast and effective therapeutic debridement through its proprietary enzymatic product, SN514, which is designed to enhance healing by selectively removing necrotic tissue.

Member
Sonogen Medical Inc.

Sonogen Medical Inc. is dedicated to researching, developing, and commercializing next-generation ultrasonic bone fracture healing technology. The company combines expertise in fluid mechanics, biophysics, sonar, and medical ultrasound to create safe and effective devices for bone healing.

Member
University of Arkansas

The Institute for Integrative & Innovative Research (I3R) at the University of Arkansas is dedicated to pioneering solutions to complex societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I3R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

Member
Neuraptive Therapeutics, Inc.

Neuraptive Therapeutics is a biotechnology company focused on developing novel therapies to improve outcomes in peripheral nerve injuries (PNI). Their mission is to enhance the quality and speed of recovery for patients suffering from traumatic injuries or undergoing reconstructive surgeries, utilizing innovative technologies such as NTX-001, a nerve fusion system, and specialized microsurgical instruments.

Member
Spartan Medical

Spartan Medical is a medical solutions company serving VA medical centers, Department of Defense (DoD) facilities, civilian hospitals, and ambulatory surgery centers across the United States and internationally. The company specializes in advanced medical devices, surgical solutions, and support services, with a history of adapting to emergent healthcare challenges and logistical demands. Spartan Medical has provided solutions in public health crises, such as COVID-19 mitigation, and delivers comprehensive procurement, logistical, and operational support for healthcare organizations. It operates as a certified Service-Disabled Veteran-Owned Small Business (SDVOSB) and is recognized for its significant presence in federal healthcare contracting.

Member
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Member
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

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Projects

Technology Showcase

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University of California San Francisco

TemPredict: AI-Driven Wearable Monitoring for Early Illness Detection and Warfighter Readiness

TemPredict: AI wearables detect early illness and health risks to support warfighter readiness.

Arizona State University

ASU Crosscutting Technologies to Enhance Military Medical Readiness and Resilience

Dr. Rachel Cassalia leads MTEC-supported efforts at ASU to shift military health from reactive care to proactive readiness through data-driven prevention.

University of Pittsburgh

Topical Metformin Lotion for Tendinopathy Prevention

University of Pittsburgh study shows topical metformin prevents overuse tendon injury. This work was sponsored through MTEC project 22-02-MPAI-014.

Theradaptive

Theradaptive’s RESTORE Trial Initiation for OsteoAdapt™ DE

Theradaptive launches RESTORE Phase I/II trial of OsteoAdapt™ DE for faster, precision bone healing in craniofacial injuries. MTEC-funded study targets improved recovery for military and civilian patients.

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