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Profusa, Inc.Profusa, Inc. is a pioneering digital health company based in the San Francisco Bay Area, dedicated to making the body’s chemistry easily accessible to improve health and wellness. Profusa develops tissue-integrating biosensors for continuous, real-time monitoring of body chemistries, empowering individuals and clinicians with actionable, medical-grade data to transform personal health management and disease prevention. Their unique bioengineering approach overcomes the foreign body response, enabling long-term, in-body monitoring through tiny, flexible biosensors that become one with the body. Profusa’s technology platform supports both consumer and medical applications, with a vision to revolutionize personalized medicine and digital health. The company is supported by significant grant funding from agencies such as DARPA and NIH, and collaborates with leading academic, hospital, and industry partners worldwide.
Profusa, Inc. is a pioneering digital health company based in the San Francisco Bay Area, dedicated to making the body’s chemistry easily accessible to improve health and wellness. Profusa develops tissue-integrating biosensors for continuous, real-time monitoring of body chemistries, empowering individuals and clinicians with actionable, medical-grade data to transform personal health management and disease prevention. Their unique bioengineering approach overcomes the foreign body response, enabling long-term, in-body monitoring through tiny, flexible biosensors that become one with the body. Profusa’s technology platform supports both consumer and medical applications, with a vision to revolutionize personalized medicine and digital health. The company is supported by significant grant funding from agencies such as DARPA and NIH, and collaborates with leading academic, hospital, and industry partners worldwide.
Publication Number
US-9867560-B2
Publication Date
2018-01-16
Expiration Date
Abstract
Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
Core Innovation
Disclosed herein are luminescent dyes, polymers comprising said dyes, and sensors comprising the polymers of the present invention. In one embodiment, the present invention relates to a compound of Formula 1 and polymers comprising as a monomer repeat unit the residue of the compound of Formula 1; the polymers provided herein can be luminescent biocompatible hydrogels. The luminescent sensors comprising the polymers are useful for detecting an analyte, e.g., oxygen, in vivo or in vitro and can produce a detectable signal in the presence of the analyte when placed (e.g., implanted) into the tissue of a subject.
Diagnosis, treatment and management of some medical conditions require monitoring of oxygen concentration in the afflicted organ or tissue, and current monitoring methods are expensive, cumbersome, time consuming, and do not provide accurate, continuous tissue oxygenation information. There is a need for a better long-term oxygen tissue monitoring system that operates non-invasively with minimal user maintenance and that has sensor longevity of days to months. Luminescence-based oxygen sensors require a highly stable dye with excitation and emission spectra in the near-infrared (NIR) optical window of the skin to enable non-invasive monitoring.
The invention further provides various luminescent sensors comprising the polymers for detecting analytes and describes that the sensors can be in the form of a powder, fabric (e.g., wound dressing), sutures, needle, rod, disk or other suitable form. In one aspect, the luminescent sensors are tissue-integrating or comprise a tissue-integrating scaffold and can provide long-term detection of the analyte(s); in another aspect the sensors can comprise an oxidase (e.g., glucose oxidase) so that consumption of oxygen by the oxidase is detected by the luminescent dye residue incorporated into the polymer.
Claims Coverage
Overview: one independent claim was identified. Four main inventive features are extracted from the independent claim.
Tissue-integrating sensor
placing a tissue-integrating sensor comprising a polymer
Polymer comprising luminescent dye residues
wherein said polymer comprises one or more residues of a luminescent dye
Photostable porphyrin dye with NIR spectra
wherein the luminescent dye is a photostable porphyrin dye and has excitation and emission spectra in the NIR optical window of a mammalian skin
Compound defined by Formula 1
wherein the luminescent dye is a compound having the formula
The independent claim recites a tissue-integrating sensor comprising a polymer that includes residues of a luminescent dye, wherein the dye is a photostable porphyrin dye with excitation and emission spectra in the NIR optical window of mammalian skin, and wherein the luminescent dye is the compound of Formula 1.
Stated Advantages
Excitation and emission wavelengths in the optical window of the skin (approximately 550 nm to 1000 nm) allowing detection of analytes deep within a tissue or an organ.
High signal-to-noise ratio and large Stokes shifts and emission.
Photostability; the dyes and/or polymers do not undergo rapid photobleaching.
Devices that generate a stable signal over a long period of time (e.g., greater than a week, greater than a month, greater than 6 months).
Sensors that are tissue-integrating, can be implanted via syringe or trocar injection without surgery, do not include sensor electronics in the body, and can have small dimensions to increase patient comfort and acceptance.
Documented Applications
Oxygen-sensing wound dressing to monitor the process of wound healing.
Powder used directly in the wound as a sensor for wound-healing monitoring.
Injectable implant, mesh or sutures for applications benefiting from monitoring oxygenation of skin or underlying tissue, including wound healing monitoring, skin closure, hernia repair, flap transfer surgeries, reconstructive surgery, and other plastic surgery applications.
Measurement for microcirculatory dysfunction and peripheral artery disease, including monitoring during revascularization procedures or upon administration of drug.
Oncology applications to determine the degree of hypoxia in a tissue or an organ and to monitor tumor growth in animal models used in oncology pharmaceutical and diagnostic research.
Monitoring the state of pulmonary function, for example in COPD and asthma disease states.
Exercise or training optimization, e.g., soldier and athlete performance or personal exercise programs.
Oxygen-sensing tattoo.
Neuroscience monitoring applications, for example continuous monitoring of oxygen in subarachnoid hemorrhage.
Semi-continuous, continuous and/or long-term use within a mammalian body.
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