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Profusa, Inc.Profusa, Inc. is a pioneering digital health company based in the San Francisco Bay Area, dedicated to making the body’s chemistry easily accessible to improve health and wellness. Profusa develops tissue-integrating biosensors for continuous, real-time monitoring of body chemistries, empowering individuals and clinicians with actionable, medical-grade data to transform personal health management and disease prevention. Their unique bioengineering approach overcomes the foreign body response, enabling long-term, in-body monitoring through tiny, flexible biosensors that become one with the body. Profusa’s technology platform supports both consumer and medical applications, with a vision to revolutionize personalized medicine and digital health. The company is supported by significant grant funding from agencies such as DARPA and NIH, and collaborates with leading academic, hospital, and industry partners worldwide.
Profusa, Inc. is a pioneering digital health company based in the San Francisco Bay Area, dedicated to making the body’s chemistry easily accessible to improve health and wellness. Profusa develops tissue-integrating biosensors for continuous, real-time monitoring of body chemistries, empowering individuals and clinicians with actionable, medical-grade data to transform personal health management and disease prevention. Their unique bioengineering approach overcomes the foreign body response, enabling long-term, in-body monitoring through tiny, flexible biosensors that become one with the body. Profusa’s technology platform supports both consumer and medical applications, with a vision to revolutionize personalized medicine and digital health. The company is supported by significant grant funding from agencies such as DARPA and NIH, and collaborates with leading academic, hospital, and industry partners worldwide.
Publication Number
US-10383557-B2
Publication Date
2019-08-20
Expiration Date
Abstract
Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
Core Innovation
Disclosed herein are luminescent dyes, polymers comprising said dyes, and sensors comprising the polymers of the present invention. The invention includes a compound of Formula 1 and polymers comprising, as monomer repeat units, the residue of the compound of Formula 1, and the polymers can be luminescent biocompatible hydrogels; the luminescent sensors comprise the polymers for detecting an analyte, e.g., oxygen, in vivo or in vitro and can be tissue-integrating or comprise a tissue-integrating scaffold and produce a detectable signal in the presence of the analyte.
Diagnosis, treatment and management of some medical conditions require monitoring of oxygen concentration in the afflicted organ or tissue, and current monitoring methods are expensive, cumbersome, time consuming, and do not provide accurate, continuous tissue oxygenation information, creating a need for a better long-term oxygen tissue monitoring system. The sensors monitored optically through the skin require a highly stable dye with excitation and emission spectra in the near-infrared optical window of the skin, high signal-to-noise ratio and photostability, and current sensors made of rigid materials differ in mechanical properties from tissue and can induce a fibrous capsule; thus improved stable, near-IR luminescent compounds and sensors for direct, rapid and accurate measurement of oxygen levels in tissue are provided.
Claims Coverage
The independent claim recites three main inventive features.
Sensor for detecting an analyte comprising a polymer
A sensor for detecting an analyte comprising a polymer.
Polymer comprising residues of a luminescent dye and HEMA
The polymer comprises one or more residues of a luminescent dye and one or more residues of 2-hydroxyethyl methacrylate (HEMA).
Luminescent dye defined by a specific compound formula
The luminescent dye is a compound having the formula recited in the claim.
The independent claim is directed to a polymer-based sensor that incorporates residues of a specified luminescent dye and HEMA, where the luminescent dye is defined by the claim formula, enabling detection of an analyte.
Stated Advantages
Excitation and emission wavelengths in the optical window of the skin (approximately 550 nm to 1000 nm) allowing detection of analytes deep within a tissue or an organ.
High signal-to-noise ratio.
Large Stokes shifts and emission.
Photostability, e.g., the dyes and/or polymers do not undergo rapid photobleaching.
Devices that generate stable signal over a long period of time (e.g., greater than a week, greater than a month, greater than 6 months).
Devices that are placed or implanted and integrate into the subject's tissue (e.g., through tissue and/or capillary in-growth).
Devices which can be implanted through syringe injection or trocar injection, meaning that no surgery is required to put the sensing media in place in the body.
Devices that do not include sensor electronics in the body.
Devices of small dimensions which result in increased patient comfort and better acceptance by the body.
Documented Applications
Wound healing monitoring, e.g., oxygen-sensing wound dressing to constantly and non-invasively assess oxygenation during wound healing.
Use in skin closure, hernia repair, flap transfer surgeries, reconstructive surgery, and other plastic surgery applications.
Measurement for microcirculatory dysfunction and peripheral artery disease, including monitoring during revascularization procedures or upon administration of drug.
Oncology applications to determine the degree of hypoxia in a tissue or an organ and to monitor tumor growth in animal models used in oncology pharmaceutical and diagnostic research.
Monitoring the state of pulmonary function, for example in COPD and asthma disease states.
Exercise or training optimization, e.g., soldier and athlete performance or personal exercise programs.
An oxygen-sensing tattoo.
Neuroscience monitoring applications, for example continuous monitoring of oxygen in subarachnoid hemorrhage.
In vitro and in vivo detection of analytes, including multi-analyte sensing where oxygen is one of two or more analytes detected.
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