Xcellon Biologics
A specialized CDMO focused on development and manufacturing of complex biologics with emphasis on antibody–drug conjugates (ADCs) and bioconjugates. Services span lead selection, conjugation process development, downstream purification, analytical and formulation development, and predictive data analytics. The organization is expanding to offer GMP manufacturing and clinical supply capabilities in Maryland.
Industries
N/A
Services
ADC & Bioconjugate Lead Selection
Screening of linker–payload options and conjugation strategies, developability assessment, and generation of in vivo‑suitable material for preclinical evaluation.
ADC & Bioconjugate Development
Conjugation optimization, DoE, DAR control, platform DSP integration, and medium-scale generation of material for toxicology and IND-enabling studies.
Bioprocess Development
Upstream and downstream process development, protein engineering, and process optimization to enable scale-up and technology transfer to manufacturing.
Analytical & Formulation Development
Identity, purity, potency, and stability testing paired with formulation optimization to establish release criteria and support regulatory submissions.
Advanced Data Analytics and Machine Learning
Integration of conjugation, purification, and stability datasets with predictive models and dashboards to forecast risks and support process decisions.
GMP Manufacturing (planned)
Planned clinical manufacturing services including GMP bioconjugation, integrated DSP, and upstream cell culture capacity to support clinical supply (facility readiness projected for 2026).
ADC & Bioconjugate Lead Selection
Screening of linker–payload options and conjugation strategies, developability assessment, and generation of in vivo‑suitable material for preclinical evaluation.
ADC & Bioconjugate Development
Conjugation optimization, DoE, DAR control, platform DSP integration, and medium-scale generation of material for toxicology and IND-enabling studies.
Bioprocess Development
Upstream and downstream process development, protein engineering, and process optimization to enable scale-up and technology transfer to manufacturing.
Analytical & Formulation Development
Identity, purity, potency, and stability testing paired with formulation optimization to establish release criteria and support regulatory submissions.
Advanced Data Analytics and Machine Learning
Integration of conjugation, purification, and stability datasets with predictive models and dashboards to forecast risks and support process decisions.
GMP Manufacturing (planned)
Planned clinical manufacturing services including GMP bioconjugation, integrated DSP, and upstream cell culture capacity to support clinical supply (facility readiness projected for 2026).
Expertise Areas
- Antibody–drug conjugate (ADC) development
- Bioconjugation and site-specific conjugation
- Analytical and formulation development for complex biologics
- Bioprocess development and scale-up
Key Technologies
- Enzymatic glycan remodeling for site-specific conjugation
- Platform downstream purification (DSP)
- Conjugation chemistries: cysteine, lysine, click chemistry, enzyme-catalyzed methods
- DAR profiling and mass-based peptide mapping