Trana Discovery Inc.
Trana Discovery is a biotechnology company specializing in proprietary drug discovery platforms targeting infectious diseases in human and agricultural applications. Their innovative technology exploits the conserved regions of transfer RNA (tRNA) to develop highly selective treatments and pesticides, addressing the growing need for new solutions against resistant pathogens and fungi. With a strong management team and proven technology platforms, Trana Discovery aims to revolutionize treatments for bacterial, viral, fungal infections, and crop diseases, while actively seeking collaborations and funding to expand their impact.
Industries
Nr. of Employees
small (1-50)
Trana Discovery Inc.
2054-260 Kildaire Farm Road, Cary, NC 27518
Patents
Compositions and methods for the identification of inhibitors of protein synthesis
US-8431341-B2
View Details
Compositions and methods for the identification of inhibitors of protein synthesis
US-8431341-B2
View DetailsProducts
High-throughput assay for HIV tRNA-dependent replication inhibitors
A validated HTS assay that uses ASL-mimic probes to identify compounds that inhibit HIV use of host tRNALys3 during replication; suitable for screening large compound libraries.
High-throughput assay for Staphylococcus aureus tRNA inhibitors
A validated HTS assay that identifies compounds interfering with a S. aureus-specific tRNAArg required for protein synthesis; includes biochemical follow-up and bacterial activity testing.
High-throughput assay for HIV tRNA-dependent replication inhibitors
A validated HTS assay that uses ASL-mimic probes to identify compounds that inhibit HIV use of host tRNALys3 during replication; suitable for screening large compound libraries.
High-throughput assay for Staphylococcus aureus tRNA inhibitors
A validated HTS assay that identifies compounds interfering with a S. aureus-specific tRNAArg required for protein synthesis; includes biochemical follow-up and bacterial activity testing.
Services
Design and execution of biochemical and cell-based HTS assays to identify compounds that inhibit pathogen-specific tRNA interactions.
Computational identification of pathogen-specific conserved tRNA sequences for use as selective diagnostic or therapeutic targets.
Licensing of validated HTS assays and lead chemistries and facilitation of collaboration agreements for development and commercialization.
Design and execution of biochemical and cell-based HTS assays to identify compounds that inhibit pathogen-specific tRNA interactions.
Computational identification of pathogen-specific conserved tRNA sequences for use as selective diagnostic or therapeutic targets.
Licensing of validated HTS assays and lead chemistries and facilitation of collaboration agreements for development and commercialization.
Expertise Areas
- Antimicrobial drug discovery
- Assay development and high-throughput screening
- Bioinformatics for target identification
- Antiviral research (tRNA-dependent mechanisms)
Key Technologies
- High-throughput screening (HTS)
- Oligonucleotide probe synthesis (ASL mimics)
- tRNA-targeted screening assays
- Bioinformatics for conserved tRNA target discovery
News & Updates
Two researchers at the University of Michigan were charged today on several counts, including smuggling the harmful Fusarium fungus into the US. Fusarium graminearum is a harmful fungus that...
Kansas is currently experiencing its largest tuberculosis (TB) outbreak in history, according to Ashley Goss, deputy secretary at the Kansas Department of Health and Environment. Speaking before...
The GRAM report, published in The Lancet, reveals a concerning trend in deaths caused by antibiotic-resistant infections. It predicts that the number of deaths will increase from 1.14 million in...
Antibiotics play a crucial role in modern medicine, helping to treat complications arising from cancer treatments, joint replacements, dialysis, organ transplants, cesarean sections, and many...
Current TB therapy requires many months of treatment with complicated medication regimens that tend to cause side effects, often leading to incomplete treatment and poor outcomes. ...
The breakthrough mRNA technology that underpins the world’s first approved COVID-19 vaccines has now emerged as a critical element of the biopharmaceutical pipeline, extending from cancer...
Two researchers at the University of Michigan were charged today on several counts, including smuggling the harmful Fusarium fungus into the US. Fusarium graminearum is a harmful fungus that...
Kansas is currently experiencing its largest tuberculosis (TB) outbreak in history, according to Ashley Goss, deputy secretary at the Kansas Department of Health and Environment. Speaking before...
The GRAM report, published in The Lancet, reveals a concerning trend in deaths caused by antibiotic-resistant infections. It predicts that the number of deaths will increase from 1.14 million in...
Antibiotics play a crucial role in modern medicine, helping to treat complications arising from cancer treatments, joint replacements, dialysis, organ transplants, cesarean sections, and many...
Current TB therapy requires many months of treatment with complicated medication regimens that tend to cause side effects, often leading to incomplete treatment and poor outcomes. ...
The breakthrough mRNA technology that underpins the world’s first approved COVID-19 vaccines has now emerged as a critical element of the biopharmaceutical pipeline, extending from cancer...