TissueVision


TissueVision is a Boston-based life sciences imaging solutions provider dedicated to helping researchers develop life-saving therapies through advanced 3D tissue imaging and analysis. With over 25 years of expertise, they offer high-throughput, non-destructive imaging services, custom assays, and comprehensive tissue analysis to pharmaceutical, biotech, and academic organizations worldwide.

Industries

biotechnology
image-recognition
product-research

Nr. of Employees

small (1-50)


Patents

Automated tissue section capture, indexing and storage system and methods

US-12135261-B2

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Systems and methods for serial staining and imaging

US-11519832-B2

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Systems and methods for imaging and processing tissue

US-10908087-B2

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Systems and methods for serial staining and imaging

US-10788403-B2

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Oscillating microtome with flexure drive

US-10054519-B2

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Systems and methods for imaging and processing tissue

US-9983134-B2

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Products

Whole-organ serial two-photon tomography imaging system

A laboratory imaging platform that combines high-speed multiphoton imaging with integrated serial sectioning to acquire high-fidelity 3D multichannel datasets of fixed tissues without optical clearing.

Automated section capture and slide-mounting module

A module that automatically captures serial tissue sections and mounts them onto glass slides with high capacity to enable downstream histology and molecular assays mapped back to the 3D dataset.

Cloud-based image analysis and data-delivery service

Processing pipelines that accept volumetric image datasets, perform registration, segmentation, quantification, and deliver full-resolution image files plus summary reports.


Services

Study execution services including consultation, study design, sample processing or acceptance of client-prepared fixed tissues, high-resolution volumetric imaging, image analysis, and final reporting.

Collaborative development and validation of tissue-specific imaging and analysis protocols across multiple tissue types, including test-sample evaluation and optimization.

Registration of brain datasets to standard atlases and generation of region-specific density maps, segmentation results, and cohort comparisons.

Whole-organ imaging and quantitative mapping of gene vector transduction efficiency and off-target distribution across organs at subcellular resolution.

Expertise Areas

  • Whole-organ 3D tissue imaging
  • High-throughput imaging pipelines and CRO services
  • Brain mapping and atlas-based registration
  • Image analysis and quantitative 3D segmentation
  • Show More (4)

Key Technologies

  • Serial two-photon tomography (multiphoton volumetric imaging)
  • Multiphoton microscopy
  • Second harmonic generation (SHG) imaging
  • Automated microtome / integrated sectioning
  • Show More (6)

News & Updates

Presentation on high-resolution spatial and temporal measurements of amyloid-beta plaque dynamics in Alzheimer's disease models.

Presentation on high-resolution imaging pipeline for amyloid-beta plaque dynamics in Alzheimer's disease models.

Comparison of 5XFAD and hAβ SAA mouse models of familial Alzheimer's disease mutations.

The company has received multiple patents and NIH grants for its innovative tissue imaging and processing technologies.


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