Small Biotechnologies
Small Biotechnologies specializes in nanoencapsulation, offering bespoke formulation development, novel automated microfluidics, and scalable production of nanocarriers such as liposomes, PLGA nanoparticles, and dendrimers. Their mission is to enable high-quality, uniform particles for advanced biomedical and pharmaceutical applications, including mRNA encapsulation, controlled release, targeted delivery, bioavailability enhancement, API solubilization, and protein stabilization.
Industries
Nr. of Employees
small (1-50)
Small Biotechnologies
London, England, United Kingdom, Europe
Products
Nanocarrier fabrication capability (liposomes, PLGA nanoparticles, dendrimers)
Scalable manufacturing capability to produce liposomes (approx. 35–400 nm), PLGA nanoparticles (approx. 50–600 nm), and dendrimer formulations (approx. 1–10 nm) for encapsulation of nucleic acids, proteins, enzymes, imaging agents, and small-molecule APIs.
Nanocarrier fabrication capability (liposomes, PLGA nanoparticles, dendrimers)
Scalable manufacturing capability to produce liposomes (approx. 35–400 nm), PLGA nanoparticles (approx. 50–600 nm), and dendrimer formulations (approx. 1–10 nm) for encapsulation of nucleic acids, proteins, enzymes, imaging agents, and small-molecule APIs.
Services
Formulation development
Design and development of nanocapsule formulations to encapsulate active components and tailor solubility, release and circulation profiles.
Process development and automation
Development of upstream and downstream processes, reaction automation, and implementation of production cycles for nanocarrier manufacture.
Scale-up and manufacturing transfer
Scale-up services that preserve product quality and ensure lot-to-lot reproducibility during industrial production.
mRNA and nucleic-acid encapsulation services
Encapsulation of mRNA and other nucleic acids into lipid-based nanocarriers with control over particle size, surface properties, and structure to support delivery needs.
Controlled-release formulation development
Design of nanocarrier-based controlled-release systems by manipulating carrier materials and particle properties to achieve targeted release profiles.
Targeted delivery development
Development of passive and active targeting strategies including surface conjugation with targeting ligands for localization of payloads.
Formulation development
Design and development of nanocapsule formulations to encapsulate active components and tailor solubility, release and circulation profiles.
Process development and automation
Development of upstream and downstream processes, reaction automation, and implementation of production cycles for nanocarrier manufacture.
Scale-up and manufacturing transfer
Scale-up services that preserve product quality and ensure lot-to-lot reproducibility during industrial production.
mRNA and nucleic-acid encapsulation services
Encapsulation of mRNA and other nucleic acids into lipid-based nanocarriers with control over particle size, surface properties, and structure to support delivery needs.
Controlled-release formulation development
Design of nanocarrier-based controlled-release systems by manipulating carrier materials and particle properties to achieve targeted release profiles.
Targeted delivery development
Development of passive and active targeting strategies including surface conjugation with targeting ligands for localization of payloads.
Expertise Areas
- Nanoencapsulation and nanocarrier design
- Continuous-flow microfluidic manufacturing
- Formulation development for nucleic acids and biologics
- Controlled-release formulation design
Key Technologies
- Continuous-flow microfluidics
- Liposomes and lipid nanoparticles
- PLGA (poly(lactic-co-glycolic acid)) nanoparticles
- Dendrimer formulations (PAMAM, PPI, tecto-types)