Sinaptica Therapeutics, Inc
Sinaptica Therapeutics is a pioneering company developing personalized, non-invasive neuromodulation therapies for Alzheimer's Disease and other neurodegenerative conditions. Their mission is to significantly slow disease progression through innovative brain stimulation techniques, leveraging advanced neuroimaging, AI, and machine learning to tailor treatments to individual patients. With a focus on safety, efficacy, and cost-effectiveness, Sinaptica aims to transform the landscape of neurodegenerative disease management and improve patient outcomes.
Industries
Nr. of Employees
small (1-50)
Sinaptica Therapeutics, Inc
Cambridge, Massachusetts, United States, North America
Products
Investigational personalized neuromodulation platform
An investigational noninvasive neuromodulation platform that integrates MRI-guided neuronavigation, stimulation hardware and concurrent electrophysiology with cloud-based algorithms to deliver individualized stimulation to targeted brain networks using an induction-plus-maintenance protocol. Intended for investigational use in clinical research.
Investigational personalized neuromodulation platform
An investigational noninvasive neuromodulation platform that integrates MRI-guided neuronavigation, stimulation hardware and concurrent electrophysiology with cloud-based algorithms to deliver individualized stimulation to targeted brain networks using an induction-plus-maintenance protocol. Intended for investigational use in clinical research.
Services
Clinical development and execution of randomized neuromodulation trials
Design and conduct of randomized, double-blind, sham-controlled clinical studies of personalized noninvasive neuromodulation, including imaging and electrophysiology sub-studies, safety monitoring, and multi-center site coordination.
Imaging and electrophysiology analysis services
Structural, microstructural and connectivity MRI analyses and extraction of stimulation-evoked electrophysiology features to evaluate biological effects of neuromodulation interventions and support biomarker development.
Device co-development and manufacturing partnership facilitation
Facilitation of development and supply collaborations with specialized stimulation, neuronavigation and electrophysiology hardware manufacturers to support clinical system development, trial deployment and scale-up to commercial production.
Public-private partnership and stakeholder engagement facilitation
Support for establishing and managing public-private collaborations involving government, industry, academia, patient-advocacy and philanthropic organizations to advance research programs and consortia.
Integration and deployment of scalable secure research data platforms
Advisory and implementation services to build or integrate secure, scalable research workbench platforms and data infrastructure to support multi-site studies and large-scale analyses.
Clinical development and execution of randomized neuromodulation trials
Design and conduct of randomized, double-blind, sham-controlled clinical studies of personalized noninvasive neuromodulation, including imaging and electrophysiology sub-studies, safety monitoring, and multi-center site coordination.
Imaging and electrophysiology analysis services
Structural, microstructural and connectivity MRI analyses and extraction of stimulation-evoked electrophysiology features to evaluate biological effects of neuromodulation interventions and support biomarker development.
Device co-development and manufacturing partnership facilitation
Facilitation of development and supply collaborations with specialized stimulation, neuronavigation and electrophysiology hardware manufacturers to support clinical system development, trial deployment and scale-up to commercial production.
Public-private partnership and stakeholder engagement facilitation
Support for establishing and managing public-private collaborations involving government, industry, academia, patient-advocacy and philanthropic organizations to advance research programs and consortia.
Integration and deployment of scalable secure research data platforms
Advisory and implementation services to build or integrate secure, scalable research workbench platforms and data infrastructure to support multi-site studies and large-scale analyses.
Expertise Areas
- Neuromodulation clinical development and trial operations
- Perturbation-based electrophysiology biomarker discovery (TMS-EEG)
- Multimodal neuroimaging and connectomics analysis (structural, diffusion, functional MRI)
- Machine learning for treatment personalization and longitudinal recalibration
Key Technologies
- Repetitive transcranial magnetic stimulation (rTMS)
- MRI-guided neuronavigation
- Concurrent stimulation and electrophysiology (TMS-EEG)
- High-density multi-channel EEG