Repligen Corporation
Repligen is a bioprocessing technology leader dedicated to advancing biopharmaceutical manufacturing. The company develops innovative solutions, including filtration systems, chromatography, analytics, and process management tools, to improve the efficiency, quality, and scalability of biologic drug production. Repligen's mission is to inspire advances in bioprocessing as a trusted partner in the production of biologic drugs that improve human health worldwide.
Industries
Nr. of Employees
Very Large (1000+)
Repligen Corporation
Repligen Corporation, 100 Binney Street, Cambridge, MA 02142, USA
Patents
Methods and systems for removing pressure and air from chromatography columns
US-11938417-B2
View Details
Methods and systems for removing pressure and air from chromatography columns
US-11938417-B2
View DetailsProducts
Automated bench and lab-scale tangential flow filtration systems (cGMP-capable)
Benchtop to lab-scale automated TFF systems that support flat sheet cassettes and hollow fiber filters, configurable pump options and multiple automated control modes; designed for integration with in-line concentration analytics for UF/DF processes.
Real-time process management TFF systems with integrated in-line spectrophotometry
Integrated solutions that combine TFF hardware with in-line variable pathlength spectrophotometry and automation software to provide continuous concentration monitoring and PAT-driven closed-loop UF/DF control.
Microfluidic CE–MS interface for rapid molecular characterization
Microfluidic capillary electrophoresis device interfaced to mass spectrometers for rapid, low-prep analysis of proteins, peptides, metabolites and oligonucleotides to support charge variant analysis, intact mass and peptide mapping workflows.
At-line media composition analyzer (multi-analyte benchtop)
Benchtop analyzer for at-line quantification of media composition (amino acids, dipeptides, choline and other components) to enable rapid media fingerprinting, process monitoring and model-driven decisions with data export capabilities.
Affinity resin pre-packed columns for nucleic acid impurity clearance
Bead-based affinity resin provided in flow-through pre-packed column formats for removal of nucleic acid impurities from process streams with scalable formats and aqueous buffer operation.
Pre-packed and miniaturized chromatography columns for process development
Pre-packed column portfolio for bench-scale screening, automated liquid handling and scale-down studies, including miniaturized formats compatible with robotic systems and exact scale-down columns for validation.
Automated bench and lab-scale tangential flow filtration systems (cGMP-capable)
Benchtop to lab-scale automated TFF systems that support flat sheet cassettes and hollow fiber filters, configurable pump options and multiple automated control modes; designed for integration with in-line concentration analytics for UF/DF processes.
Real-time process management TFF systems with integrated in-line spectrophotometry
Integrated solutions that combine TFF hardware with in-line variable pathlength spectrophotometry and automation software to provide continuous concentration monitoring and PAT-driven closed-loop UF/DF control.
Microfluidic CE–MS interface for rapid molecular characterization
Microfluidic capillary electrophoresis device interfaced to mass spectrometers for rapid, low-prep analysis of proteins, peptides, metabolites and oligonucleotides to support charge variant analysis, intact mass and peptide mapping workflows.
At-line media composition analyzer (multi-analyte benchtop)
Benchtop analyzer for at-line quantification of media composition (amino acids, dipeptides, choline and other components) to enable rapid media fingerprinting, process monitoring and model-driven decisions with data export capabilities.
Affinity resin pre-packed columns for nucleic acid impurity clearance
Bead-based affinity resin provided in flow-through pre-packed column formats for removal of nucleic acid impurities from process streams with scalable formats and aqueous buffer operation.
Pre-packed and miniaturized chromatography columns for process development
Pre-packed column portfolio for bench-scale screening, automated liquid handling and scale-down studies, including miniaturized formats compatible with robotic systems and exact scale-down columns for validation.
Services
On-site equipment installation, execution of qualification protocols and provision of documentation to integrate systems into quality management frameworks.
Scheduled calibration, preventative maintenance, spare parts provisioning and engineered installation of replacement parts to maintain instrument performance.
Engineering services to integrate analytic measurements with existing automation, control or SCADA systems and to implement feed control based on in-line measurements.
Field application scientist support, process consultation and technical assistance for product implementation and process optimization.
Application-level services including method development, implementation assistance, validation support and user training for variable pathlength spectroscopy and inline analytic techniques.
On-site equipment installation, execution of qualification protocols and provision of documentation to integrate systems into quality management frameworks.
Scheduled calibration, preventative maintenance, spare parts provisioning and engineered installation of replacement parts to maintain instrument performance.
Engineering services to integrate analytic measurements with existing automation, control or SCADA systems and to implement feed control based on in-line measurements.
Field application scientist support, process consultation and technical assistance for product implementation and process optimization.
Application-level services including method development, implementation assistance, validation support and user training for variable pathlength spectroscopy and inline analytic techniques.
Expertise Areas
- Tangential flow filtration and ultrafiltration/diafiltration process control
- Process analytical technology for concentration measurement using variable pathlength spectroscopy
- Inline metabolite monitoring and automated feed control
- Single-use fluid path design and supply-chain support for bioprocesses
Key Technologies
- Tangential flow filtration (TFF)
- Variable pathlength UV-Vis spectroscopy (slope-based spectroscopy)
- In-line spectrophotometry with removable flow cells
- Capillary electrophoresis–mass spectrometry (CE–MS)
News & Updates
Repligen will participate in the conference held January 13-16 in San Francisco, with CEO Olivier Loeillot presenting on January 14.
The company announced the commercial launch of its advanced UV-based concentration measurement system for biopharmaceutical workflows.
Introduction of the first holder-free, self-contained TFF device for biologics manufacturing.
Acquisition of Swedish magnetic mixing technology innovator to strengthen Fluid Management franchise.
Addition of single-use bioprocessing bags and assemblies to expand product portfolio.
Repligen will participate in the conference held January 13-16 in San Francisco, with CEO Olivier Loeillot presenting on January 14.
The company announced the commercial launch of its advanced UV-based concentration measurement system for biopharmaceutical workflows.
Introduction of the first holder-free, self-contained TFF device for biologics manufacturing.
Acquisition of Swedish magnetic mixing technology innovator to strengthen Fluid Management franchise.
Addition of single-use bioprocessing bags and assemblies to expand product portfolio.