Phythera Therapeutics


Phythera Therapeutics, Inc is a biotechnology company dedicated to creating breakthrough cancer medicines by improving formulas derived from plants. They leverage recent scientific advancements such as liposomal drug delivery, small molecule conjugation, and AI-driven drug design to develop efficacious and safe oncology treatments with minimal harmful impact on health and quality of life. Their mission is to convert nature-derived anti-cancer compounds into prescription drugs, not nutraceuticals, and they aim to utilize the FDA’s botanical drug regulatory pathway to develop plant extracts into prescription cancer drugs. Their vision involves modulating multiple molecular pathways activated in complex diseases like cancer using mixtures of bioactive molecules from medicinal plants, with a focus on botanical drugs and traditional approaches to discover new efficacious small molecules. They emphasize the power of drug cocktails to attack cancers through different mechanisms, limiting resistance, and are exploring the development of botanical drugs under the FDA’s new guidance. The company is actively involved in research, development, and clinical trial preparations, with a team of experienced scientists and medical professionals. They are engaged in various conferences, funding efforts, and collaborations to advance their innovative therapies.

Industries

biotechnology
life-science
therapeutics

Nr. of Employees

small (1-50)

Phythera Therapeutics

103 Rockview, Irvine, CA 92612 (Head Quarters)


Products

Enhanced botanical oncology drug candidate (composition-of-matter patent pending)

First enhanced botanical drug candidate derived from a plant with historical anti-cancer use; modified via a molecular enhancement process to improve efficacy and pharmaceutical properties and intended for development as a prescription oncology treatment.


Services

Design and execution of cell-based, organoid, and animal-model studies to evaluate efficacy and mechanism of candidate botanical-derived compounds.

Formulation services focused on liposomal delivery and medicinal-chemistry modifications to improve ADME and tissue penetration of botanical-derived compounds.

Genomic and epigenomic data analysis (RNA-Seq, ATAC-Seq, DNA methylation) to support target identification, mechanism studies, and biomarker development.

Regulatory planning that leverages FDA botanical drug guidance and experience in IND/Pre-IND documentation to prepare IND-enabling studies and submissions.

Investor engagement, grant application support (e.g., NIH SBIR), and partnering with CDMOs and pharma for development and commercialization.

Expertise Areas

  • Botanical drug development
  • Oncology small-molecule drug discovery
  • Formulation and drug delivery (liposomal)
  • Medicinal chemistry and small-molecule conjugation
  • Show More (7)

Key Technologies

  • Organoids and 3D cell culture
  • Next-generation sequencing (RNA-Seq, ATAC-Seq)
  • Proteomics
  • Advanced microscopy and imaging
  • Show More (6)

News & Updates

Phythera advanced to Round 2 Quarter-Finals, showcasing growth potential and business strategy.

Attended in Irvine, CA, on May 22, 2025, to connect with biotech community.

Participated in the conference at Hyatt Regency Newport Beach, CA, on September 25-26, 2024.

Attended organized by San Diego Connect on September 24, 2024.

NIH Grant Application Submission

Submitted the second grant application on September 4, 2024, with UCI as collaborator.

Participated in San Diego from June 3-6, 2024, and attended Bullpen BIO events.

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