Phio Pharmaceuticals
Phio Pharmaceuticals is a biotechnology company focused on developing the next generation of immuno-oncology therapeutics based on its proprietary self-delivering RNAi (INTASYL™) platform. The company aims to silence tumor-induced immune suppression and develop powerful therapeutic compounds to overcome tumor immune escape, providing innovative treatment options beyond current modalities. It is publicly traded on Nasdaq and has recently satisfied Nasdaq listing requirements.
Industries
Nr. of Employees
small (1-50)
Phio Pharmaceuticals
Marlborough, Massachusetts, United States, North America
Products
siRNA therapeutic candidate targeting PD-1 (preclinical/clinical transition)
An siRNA therapeutic designed to reduce PD-1 receptor expression in T cells for use in ex vivo cell manufacturing and/or localized intratumoral administration to achieve checkpoint modulation.
siRNA therapeutic candidate targeting TIGIT (preclinical)
An siRNA therapeutic designed to silence TIGIT expression in T cells and NK cells to increase cytotoxic activity against tumors; evaluated for intratumoral delivery and adoptive cell therapy applications.
siRNA therapeutic candidate targeting BRD4 (preclinical)
An siRNA candidate targeting BRD4 intended to modulate T cell differentiation toward effector memory phenotypes to improve persistence and functional responses in immunotherapy contexts.
siRNA therapeutic candidate targeting PD-1 (preclinical/clinical transition)
An siRNA therapeutic designed to reduce PD-1 receptor expression in T cells for use in ex vivo cell manufacturing and/or localized intratumoral administration to achieve checkpoint modulation.
siRNA therapeutic candidate targeting TIGIT (preclinical)
An siRNA therapeutic designed to silence TIGIT expression in T cells and NK cells to increase cytotoxic activity against tumors; evaluated for intratumoral delivery and adoptive cell therapy applications.
siRNA therapeutic candidate targeting BRD4 (preclinical)
An siRNA candidate targeting BRD4 intended to modulate T cell differentiation toward effector memory phenotypes to improve persistence and functional responses in immunotherapy contexts.
Services
Preclinical in vivo efficacy and mechanism studies
Design and execution of murine tumor model studies to evaluate antitumor activity, mechanism-of-action endpoints, immune infiltration, biomarker changes, and tolerability for siRNA candidates.
Adoptive cell therapy enhancement collaborations
Collaborative programs to integrate transient siRNA-based modulation into cell manufacturing workflows to improve immune effector function without permanent genetic modification.
IND-enabling preclinical and regulatory support
Coordination and execution of preclinical studies and preparatory activities required to support regulatory submissions and early-phase clinical trial initiation.
Research collaboration, licensing and partnership programs
Formation of collaborative research agreements, option arrangements and licensing partnerships with academic and industry groups to accelerate target discovery and candidate development.
Scientific conference presentations and investor outreach
Preparation and delivery of scientific posters, oral presentations and investor webcasts to disseminate preclinical data and company updates at scientific and investor conferences.
Preclinical in vivo efficacy and mechanism studies
Design and execution of murine tumor model studies to evaluate antitumor activity, mechanism-of-action endpoints, immune infiltration, biomarker changes, and tolerability for siRNA candidates.
Adoptive cell therapy enhancement collaborations
Collaborative programs to integrate transient siRNA-based modulation into cell manufacturing workflows to improve immune effector function without permanent genetic modification.
IND-enabling preclinical and regulatory support
Coordination and execution of preclinical studies and preparatory activities required to support regulatory submissions and early-phase clinical trial initiation.
Research collaboration, licensing and partnership programs
Formation of collaborative research agreements, option arrangements and licensing partnerships with academic and industry groups to accelerate target discovery and candidate development.
Scientific conference presentations and investor outreach
Preparation and delivery of scientific posters, oral presentations and investor webcasts to disseminate preclinical data and company updates at scientific and investor conferences.
Expertise Areas
- RNA interference (RNAi) therapeutics
- Immuno-oncology drug development
- Adoptive cell therapy process integration
- Local (intratumoral) therapeutic delivery
Key Technologies
- Self-delivering / delivery-enabled siRNA
- Intratumoral delivery techniques
- Ex vivo immune cell programming
- siRNA-mediated gene silencing of checkpoints and regulatory targets