OrsoBio, Inc


OrsoBio is a clinical-stage biopharmaceutical company dedicated to developing first-in-class therapies to treat severe metabolic disorders by addressing their root causes. Their mission is to redefine treatment by targeting fundamental pathways of energy metabolism with innovative therapies. The company has a diverse pipeline of programs including ACC2 inhibitors, LXR inverse agonists, mitochondrial protonophores, and ACMSD inhibitors, aimed at conditions such as obesity, diabetes, dyslipidemias, NASH, and organ failure. With a team of experienced physicians and scientists, and collaborations with leading academic institutions and investors, OrsoBio is committed to advancing therapies that restore energy homeostasis and improve patient outcomes.

Industries

biotechnology
health-care

Nr. of Employees

small (1-50)


Patents

LXR modulators with bicyclic core moiety

US-12291523-B2

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Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives

US-12049439-B2

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LXR modulators with bicyclic core moiety

US-11970484-B2

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Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors

US-11780812-B2

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LXR modulators with bicyclic core moiety

US-11618747-B2

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Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives

US-11136290-B2

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Products

TLC-6740

An oral, liver-targeted mitochondrial protonophore designed to increase energy expenditure and improve metabolic health in patients with obesity and related disorders.

TLC-3595

A selective ACC2 inhibitor aimed at enhancing fatty acid oxidation and improving insulin sensitivity in type 2 diabetes patients.

TLC-2716

A liver-targeted LXR inverse agonist developed to lower plasma triglycerides and cholesterol in severe hypertriglyceridemia and NASH.

ACMSD Inhibition

A therapeutic approach to increase NAD+ biosynthesis and enhance mitochondrial function in liver and kidney disorders.


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