NorthLinks Bio


Clinical-stage biopharmaceutical company developing a glycan-targeted, intranasal prophylactic designed to block respiratory virus attachment at the nasal mucosa. Lead investigational candidate completed Phase 1 and a Phase 2 controlled human influenza challenge study with reported reductions in symptomatic influenza and comparable safety to placebo. Platform is based on engineered multivalent carbohydrate-binding modules intended for scalable recombinant manufacture and broad activity across multiple respiratory viruses.

Industries

Biotechnology
Genetics
Biotechnology Research

Nr. of Employees

small (1-50)

NorthLinks Bio

Boston, Massachusetts, United States


Patents

Viral treatment

US-11819534-B2

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Modified protein

US-11466059-B2

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Adjuvants

US-11406704-B2

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Treatment and/or prevention of sepsis

US-10953078-B2

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Immunomodulatory compounds

US-10363298-B2

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Carbohydrate binding molecules

US-9066894-B2

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Products

HEX17

Investigational intranasal multivalent glycan-binding protein developed as a broad-spectrum antiviral prophylactic intended to block respiratory virus attachment at the nasal mucosa.

Expertise Areas

  • Clinical trial management (including human challenge models)
  • Protein engineering and engineered biologics
  • Intranasal/respiratory drug delivery
  • CMC and scale-up for biologics
  • Show More (4)

Key Technologies

  • Multivalent carbohydrate-binding modules (CBMs)
  • Recombinant protein expression in E. coli
  • Self-assembling trimerization domains
  • Intranasal spray delivery
  • Show More (4)

News & Updates

Peer-reviewed Phase II study report describing CHIM results for the investigational intranasal antiviral.

Review/article describing an intranasal glycan-targeted biotherapeutic and its preclinical profile.

Research article on host-receptor targeting using engineered proteins.

Company announced launch with $34 million financing to advance broad-spectrum respiratory antiviral platform.


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