InvisiShield Technologies, Ltd.


Pre-clinical-stage biotechnology company developing intranasal preventive therapies to neutralize airborne respiratory viruses at the nasal mucosa. The organization develops a platform that combines a pathogen-binding component, a virus-killing mechanism that activates complement, and a formulation approach to increase nasal retention. Lead development is an intranasal topical preventive intended to provide immediate, short-term protection against SARS-CoV-2, with the platform being applied to influenza and RSV. Headquartered in Emeryville, California.

Industries

N/A

Nr. of Employees

small (1-50)


Patents

Compositions for preventing or treating coronavirus infections

US-12460193-B2

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Chimeric protein comprising an anti-influenza virus antibody moiety and a mucoadhesive peptide fragment for preventing or treating influenza infections

US-12459988-B2

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Compositions for preventing or treating viral and other microbial infections

US-11440952-B2

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Products

Intranasal COVID-19 preventive spray (lead candidate)

Pre-clinical intranasal topical formulation designed to bind and neutralize SARS-CoV-2 in the nasal cavity, incorporating enhanced mucosal retention and a complement-activating killing mechanism. Demonstrated prevention of infection in cell-based assays and at least 10 hours of protection in mouse challenge studies at the lowest tested dose.

IS101

An intranasal COVID-19 preventive spray that provides daily protection on the nasal cavity surface, the principal portal of viral entry.

InvisiShield COVID-19 intranasal preventive (IS101)

A topical daily use nasal spray designed to provide immediate protection against SARS-CoV-2 infection by binding the virus and using proprietary nasal retention technology to capture and kill all major current and potential future variants in the nasal cavity.

InvisiShield's COVID-19 intranasal preventive spray

An intranasal spray designed to prevent SARS-CoV-2 infection by providing protection at the nasal mucosa, the primary entry point for the virus.

Expertise Areas

  • Intranasal drug delivery and mucosal formulations
  • Preclinical virology and immunology research
  • In vivo infectious disease models (mouse challenge studies)
  • In vitro pseudotyped-virus neutralization assays
  • Show More (4)

Key Technologies

  • Intranasal drug delivery
  • Mucosal adhesion / nasal retention formulations
  • Pathogen-binding biologic agents
  • Complement activation–based viral neutralization
  • Show More (3)

News & Updates

Announcement of a scientific advisory board composed of experts in virology and immunology to advise preclinical development.

Collaboration to accelerate development of intranasal preventatives against SARS-CoV-2, influenza, and RSV including partnered preclinical studies and access to BSL-3 testing facilities.

Announcement of appointment of a senior virology researcher to lead scientific strategy and accelerate clinical development pathways.


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