Next-Trillion Science
NextTrillionSciences specializes in rapid academic research and development services in clinical science, offering in vivo and in vitro testing, clinical trial management, and research-backed recommendations. Their mission is to perform academic research at the speed demanded by clinical research, supporting companies across all phases of product development with strategic academic lab partnerships and comprehensive testing capabilities. The company also conducts advanced microbiome and biofilm research, including studies on bacterial and fungal interactions, biofilm formation, and microbial resistance mechanisms, contributing to understanding complex microbial ecosystems and their role in diseases such as Crohn's disease and oral cancers.
Industries
Nr. of Employees
small (1-50)
Next-Trillion Science
Cleveland, Ohio, United States, North America
Products
Antifungal Therapy (book, 2nd edition)
Edited reference summarizing clinical mycology and antifungal treatment recommendations, dosing and pharmacology for clinicians and researchers.
Lipids of Pathogenic Fungi (book)
Academic volume discussing lipid composition, metabolism and roles in fungal pathogenicity and potential antifungal targets.
Antifungal Therapy (book, 2nd edition)
Edited reference summarizing clinical mycology and antifungal treatment recommendations, dosing and pharmacology for clinicians and researchers.
Lipids of Pathogenic Fungi (book)
Academic volume discussing lipid composition, metabolism and roles in fungal pathogenicity and potential antifungal targets.
Services
Design and execution of in vitro biofilm formation and susceptibility assays on device-relevant substrates with microscopy and quantitative readouts.
Animal-model studies for catheter-associated biofilms, contact lens infections and disseminated fungal infections to evaluate therapeutic candidates and device interactions with quantitative culture and imaging endpoints.
Operational support for clinical studies including sample handling, central-lab testing coordination and multi-site study execution for infection- and dermatology-focused trials.
16S rRNA and shotgun metagenomic sequencing workflows with downstream computational analysis for taxonomic profiling, diversity metrics and interkingdom correlation studies.
Confocal, fluorescence, scanning and transmission electron microscopy services for 2D/3D biofilm architecture analysis and image-based quantification.
Screening of probiotic strains and formulations for prevention and treatment of polymicrobial biofilms using functional and phenotypic assays.
Design and execution of in vitro biofilm formation and susceptibility assays on device-relevant substrates with microscopy and quantitative readouts.
Animal-model studies for catheter-associated biofilms, contact lens infections and disseminated fungal infections to evaluate therapeutic candidates and device interactions with quantitative culture and imaging endpoints.
Operational support for clinical studies including sample handling, central-lab testing coordination and multi-site study execution for infection- and dermatology-focused trials.
16S rRNA and shotgun metagenomic sequencing workflows with downstream computational analysis for taxonomic profiling, diversity metrics and interkingdom correlation studies.
Confocal, fluorescence, scanning and transmission electron microscopy services for 2D/3D biofilm architecture analysis and image-based quantification.
Screening of probiotic strains and formulations for prevention and treatment of polymicrobial biofilms using functional and phenotypic assays.
Expertise Areas
- Clinical trial coordination and centralized laboratory operations
- Preclinical infectious disease models and device-associated infection research
- Biofilm assay development and quantitative phenotyping
- Microbiome sequencing, metagenomics and taxonomic profiling
Key Technologies
- Confocal fluorescence microscopy
- Scanning electron microscopy (SEM)
- Transmission electron microscopy (TEM)
- Image-based 3D reconstruction of biofilms
News & Updates
A clinically relevant rabbit model to evaluate the morphology, topography, and architecture of fungal biofilms on catheters, useful for testing lock solutions and characterizing biofilm formation.
Study on the critical role of oral microbiome organisms and their collective genome in health and disease, focusing on the fungal component.
A clinically relevant rabbit model to evaluate the morphology, topography, and architecture of fungal biofilms on catheters, useful for testing lock solutions and characterizing biofilm formation.
Study on the critical role of oral microbiome organisms and their collective genome in health and disease, focusing on the fungal component.