LEIBNIZ:HKI
Leibniz-HKI is dedicated to natural product research and infection biology, focusing on developing innovative therapies, understanding microbial interactions, and advancing biotechnological processes. The institute collaborates with industry and academia to address challenges such as antimicrobial resistance and fungal infections, aiming to translate scientific findings into practical applications.
Industries
Nr. of Employees
medium (51-250)
LEIBNIZ:HKI
Products
UHPLC-based analytical platform (core facility)
Ultra-high-performance liquid chromatography instrumentation and analytical support for metabolomics and natural-product separations.
Pilot-scale bioprocess infrastructure (Biotechnikum)
Infrastructure enabling end-to-end process chains from microtiter screening to pilot-scale production, including reactors up to ~4.5 m^3 gross volume and downstream purification systems; supports multiple cultivation modes including chemostat, anaerobic and high-cell-density fermentations.
Microfluidic droplet screening platform with integrated multiparametric detection
Platform for picoliter-scale droplet cultivation, combined image- and optical-signal acquisition, image-based droplet sorting and barcode-based droplet identification, enabling ultrahigh-throughput screening and downstream recovery/analysis of selected droplets.
UHPLC-based analytical platform (core facility)
Ultra-high-performance liquid chromatography instrumentation and analytical support for metabolomics and natural-product separations.
Pilot-scale bioprocess infrastructure (Biotechnikum)
Infrastructure enabling end-to-end process chains from microtiter screening to pilot-scale production, including reactors up to ~4.5 m^3 gross volume and downstream purification systems; supports multiple cultivation modes including chemostat, anaerobic and high-cell-density fermentations.
Microfluidic droplet screening platform with integrated multiparametric detection
Platform for picoliter-scale droplet cultivation, combined image- and optical-signal acquisition, image-based droplet sorting and barcode-based droplet identification, enabling ultrahigh-throughput screening and downstream recovery/analysis of selected droplets.
Services
Antimicrobial screening assays
Target-based and whole-cell screening services for discovery of antibacterial and antifungal lead compounds, including custom assay design and laboratory optimization for screening campaigns.
Bioprocess development and scale-up (upstream and downstream)
End-to-end process development from microscale screening to pilot-scale cultivation (up to 4.5 m^3 gross volume) and downstream purification to produce material for preclinical research, supporting multiple cultivation modes and anaerobic/high-cell-density processes.
Microfluidic droplet screening and integrated data-capture services
Droplet-based cultivation and ultrahigh-throughput screening including multiparametric optical and image acquisition, real-time image-based droplet classification/sorting and barcode-based droplet identification, with downstream recovery or analysis of selected droplets.
Automated image-analysis software and pipeline development
Development and delivery of analysis pipelines for preprocessing, segmentation, classification and tracking of microscopy images and time-lapse data applied to infection-biology assays and high-content screening.
Organ-on-chip model development and testing
Design and application of organ-on-chip systems to study host–pathogen interactions and host–microbiota dynamics for testing targeted therapies.
Antifungal resistance surveillance support and consultancy
Support for establishing epidemiological surveillance systems and interpretation of resistance data to inform treatment strategies and research priorities.
Antimicrobial screening assays
Target-based and whole-cell screening services for discovery of antibacterial and antifungal lead compounds, including custom assay design and laboratory optimization for screening campaigns.
Bioprocess development and scale-up (upstream and downstream)
End-to-end process development from microscale screening to pilot-scale cultivation (up to 4.5 m^3 gross volume) and downstream purification to produce material for preclinical research, supporting multiple cultivation modes and anaerobic/high-cell-density processes.
Microfluidic droplet screening and integrated data-capture services
Droplet-based cultivation and ultrahigh-throughput screening including multiparametric optical and image acquisition, real-time image-based droplet classification/sorting and barcode-based droplet identification, with downstream recovery or analysis of selected droplets.
Automated image-analysis software and pipeline development
Development and delivery of analysis pipelines for preprocessing, segmentation, classification and tracking of microscopy images and time-lapse data applied to infection-biology assays and high-content screening.
Organ-on-chip model development and testing
Design and application of organ-on-chip systems to study host–pathogen interactions and host–microbiota dynamics for testing targeted therapies.
Antifungal resistance surveillance support and consultancy
Support for establishing epidemiological surveillance systems and interpretation of resistance data to inform treatment strategies and research priorities.
Expertise Areas
- Antifungal drug discovery
- Natural product chemistry and biosynthetic pathway analysis
- Bioprocess development and fermentation scale-up (including chemostat and high-cell-density cultivation)
- Droplet microfluidics and ultrahigh-throughput screening
Key Technologies
- Picoliter droplet microreactors
- Integrated multiparametric optical detection (fluorescence, absorption, scattered-light, imaging)
- Droplet digital PCR (ddPCR)
- Ultra-high-performance liquid chromatography (UHPLC)