NCCR Molecular Systems Engineering
A Swiss National Centre of Competence in Research hosted by the University of Basel and ETH Zurich. Performs interdisciplinary research in systems chemistry, synthetic biology and biomolecular engineering to design molecular systems and cellular technologies for synthesis, diagnostics, therapeutics and tissue restoration. Also conducts technology transfer, organized scientific events, public engagement and embedded ethics activities.
Industries
Nr. of Employees
medium (51-250)
NCCR Molecular Systems Engineering
University of Basel, Mattenstrasse 24a / Mattenstrasse 22, CH-4002 Basel, Switzerland
Products
Engineered Cartilage Implants
Cartilage implants developed from nasal septum cells to treat complex knee injuries and potentially osteoarthritis.
Gene Switch Activated by Nitroglycerine Patch
A gene switch technology activated by a nitroglycerine skin patch to control cell therapies for metabolic diseases.
Gene Correction Therapy for Stargardt Disease
A gene correction therapy developed to treat Stargardt disease, an inherited form of macular degeneration causing vision loss.
CRISPR-Based Gene Variant Analysis Method
A method combining two gene editing techniques to rapidly assess the impact of genetic mutations related to cancer development and treatment.
Synthetic Protocells with Cell-Cell Communication
Synthetic protocells engineered to emulate natural cellular communication, including artificial organelles and environmental sensitivity.
Microbial Cell Factories for Cycloalkene Synthesis
A whole-cell hybrid biocatalytic system combining natural and artificial enzymes to produce cycloalkenes from fatty diacids.
Engineered Cartilage Implants
Cartilage implants developed from nasal septum cells to treat complex knee injuries and potentially osteoarthritis.
Gene Switch Activated by Nitroglycerine Patch
A gene switch technology activated by a nitroglycerine skin patch to control cell therapies for metabolic diseases.
Gene Correction Therapy for Stargardt Disease
A gene correction therapy developed to treat Stargardt disease, an inherited form of macular degeneration causing vision loss.
CRISPR-Based Gene Variant Analysis Method
A method combining two gene editing techniques to rapidly assess the impact of genetic mutations related to cancer development and treatment.
Synthetic Protocells with Cell-Cell Communication
Synthetic protocells engineered to emulate natural cellular communication, including artificial organelles and environmental sensitivity.
Microbial Cell Factories for Cycloalkene Synthesis
A whole-cell hybrid biocatalytic system combining natural and artificial enzymes to produce cycloalkenes from fatty diacids.
Services
Events and structured collaboration opportunities to connect researchers with industry partners, including an annual technology event and a Technology Collaboration Program.
Interdisciplinary education activities including seminars, summer schools, fellow retreats, career workshops and exchange training programs across participating groups.
Ethics advisory services for projects, public seminars, art–science collaborations and think-tank activities to integrate societal and ethical perspectives into research.
A public lecture series featuring international scientists who present research and key concepts in formats accessible to a broad audience.
Collaborative projects using artistic media to communicate molecular systems engineering concepts and foster public dialogue.
Events and structured collaboration opportunities to connect researchers with industry partners, including an annual technology event and a Technology Collaboration Program.
Interdisciplinary education activities including seminars, summer schools, fellow retreats, career workshops and exchange training programs across participating groups.
Ethics advisory services for projects, public seminars, art–science collaborations and think-tank activities to integrate societal and ethical perspectives into research.
A public lecture series featuring international scientists who present research and key concepts in formats accessible to a broad audience.
Collaborative projects using artistic media to communicate molecular systems engineering concepts and foster public dialogue.
Expertise Areas
- Molecular systems engineering
- Synthetic biology and synthetic cells
- Biocatalysis and enzyme engineering
- Microfluidics and high-throughput screening
Key Technologies
- CRISPR and gene-editing methods
- Artificial metalloenzymes
- Enzyme engineering
- Droplet microfluidics
News & Updates
Conference on creating functional molecular systems held in Basel.
Conference addressing ethical aspects of engineering living systems, organized with international partners and stakeholders.
Two-day conference convening researchers, clinicians and ethicists to discuss ethical implications of engineering-life approaches.
One-day symposium on the ethics and state-of-the-art of engineering biology, with presentations and an international ethics panel.
Workshop supporting scientist-entrepreneurs and technology translation.
Demonstration that lateral lipid phase separation can be controlled by a surface-anchored artificial catalyst.
Conference on creating functional molecular systems held in Basel.
Conference addressing ethical aspects of engineering living systems, organized with international partners and stakeholders.
Two-day conference convening researchers, clinicians and ethicists to discuss ethical implications of engineering-life approaches.
One-day symposium on the ethics and state-of-the-art of engineering biology, with presentations and an international ethics panel.
Workshop supporting scientist-entrepreneurs and technology translation.
Demonstration that lateral lipid phase separation can be controlled by a surface-anchored artificial catalyst.