Nautilus Biotechnology
Developer of single-molecule proteomics instruments and workflows that detect and digitally count individual protein molecules and proteoforms. Combines instrument and array engineering, affinity-reagent and assay development, nanoparticle conjugation, and computational analysis (including machine learning) to enable proteoform-resolved biomarker discovery, spatial proteomics, and translational research. Public activities emphasize reproducible computational workflows, open data formats, educational resources, early-access and grant programs, and participation in community data and standards initiatives. The company has published large-scale single-molecule proteoform analyses and distributes technical notes, blog posts, and a podcast discussing methods and applications.
Industries
Nr. of Employees
medium (51-250)
Nautilus Biotechnology
Patents
Products
Research platform for single-molecule proteome and proteoform analysis
Research instrument and associated workflows that apply patterned ultra-dense arrays, nanoparticle-based capture, iterative cyclical probing with multi-affinity probes, and computational decoding to measure proteins and proteoforms with digital counting for discovery and targeted assays.
Proteoform-targeted assay panels (research use)
Assay panels designed to quantify sets of proteoforms, including isoform- and modification-resolved panels for disease research, with validated analytical performance for research samples and model systems.
Research platform for single-molecule proteome and proteoform analysis
Research instrument and associated workflows that apply patterned ultra-dense arrays, nanoparticle-based capture, iterative cyclical probing with multi-affinity probes, and computational decoding to measure proteins and proteoforms with digital counting for discovery and targeted assays.
Proteoform-targeted assay panels (research use)
Assay panels designed to quantify sets of proteoforms, including isoform- and modification-resolved panels for disease research, with validated analytical performance for research samples and model systems.
Services
Programmatic access for selected external researchers to trial single-molecule proteomics workflows via small-scale experiments; includes data analysis and reporting, assistance with dissemination (conference presentations and manuscript support), and grant-supported collaborative studies.
Podcasts, webinars, technical notes and blog resources covering proteome complexity, proteoforms, computational reproducibility, spatial proteomics, and applications of proteomics in translational research.
Programmatic access for selected external researchers to trial single-molecule proteomics workflows via small-scale experiments; includes data analysis and reporting, assistance with dissemination (conference presentations and manuscript support), and grant-supported collaborative studies.
Podcasts, webinars, technical notes and blog resources covering proteome complexity, proteoforms, computational reproducibility, spatial proteomics, and applications of proteomics in translational research.
Expertise Areas
- Single-molecule proteomics and proteoform analysis
- Short-epitope mapping and multi-affinity probe development
- Ultra-dense nanoarray design and nanoparticle conjugation
- Instrument engineering and laboratory automation for high-throughput platforms
Key Technologies
- Ultra-dense single-molecule nanoarrays
- Nanoparticle-based single-protein capture and click-chemistry conjugation
- Short-epitope mapping with multi-affinity probe panels
- Iterative cyclical probing for single-molecule identification
News & Updates
Blog coverage of conference participation highlighting platform applications and promotion of a first-access challenge that selects researchers for early use of the single-molecule proteomics workflow.
Announcement of a research collaboration with academic and foundation partners to advance single-molecule proteomics research in Parkinson’s disease.
Peer-reviewed publication reporting large-scale single-molecule analysis and quantitation of tau proteoforms across model systems and patient samples.
Podcast series episodes and transcripts discussing proteome complexity, proteoforms, computational reproducibility, spatial proteomics, AI in experimental design, and translational applications of proteomics.
Technical description of patterned chip design, nanoparticle production, click-chemistry conjugation, and testing showing low frequency of multiple proteins per landing pad.
Overview page describing iterative cyclical probing workflows, benefits (coverage, accuracy, reproducibility, scalability), and integrated cloud analysis for single-molecule proteomics.
Blog coverage of conference participation highlighting platform applications and promotion of a first-access challenge that selects researchers for early use of the single-molecule proteomics workflow.
Announcement of a research collaboration with academic and foundation partners to advance single-molecule proteomics research in Parkinson’s disease.
Peer-reviewed publication reporting large-scale single-molecule analysis and quantitation of tau proteoforms across model systems and patient samples.
Podcast series episodes and transcripts discussing proteome complexity, proteoforms, computational reproducibility, spatial proteomics, AI in experimental design, and translational applications of proteomics.
Technical description of patterned chip design, nanoparticle production, click-chemistry conjugation, and testing showing low frequency of multiple proteins per landing pad.
Overview page describing iterative cyclical probing workflows, benefits (coverage, accuracy, reproducibility, scalability), and integrated cloud analysis for single-molecule proteomics.