NanoTag Biotechnologies
Provider of single-domain antibody (sdAb) discovery, engineered sdAb reagents, affinity selector resins and custom protein services for research and preclinical applications. Offers animal immunization and library-based discovery workflows, affinity-based B-cell selection, site-specific fluorophore conjugation with defined stoichiometry, fixation-enhancing tags for microscopy, recombinant sdAb–Fc fusions, bispecific sdAb constructs, selector resins for tag-based purification, and CRO-style expression, purification and conjugation services. Publishes protocols, manuals and safety data sheets for products and documents licensing restrictions for certain materials.
Industries
Nr. of Employees
small (1-50)
NanoTag Biotechnologies
Rudolf-Wissell-Straße 28A, 37079 Göttingen, Germany
Patents
Products
Fluorophore-conjugated single-domain antibody reagents (single- and multi-dye)
Fluorescently labeled sdAb reagents with defined numbers of fluorophores at known positions available in single-fluorophore (quantitative) and multi-fluorophore formats for high-sensitivity imaging and super-resolution applications.
Affinity selector resins for tagged proteins (agarose and magnetic)
Covalently immobilized sdAbs on cross-linked agarose or magnetic beads for capture and purification of tagged proteins and fusions; oriented attachment reduces non-specific binding and preserves functionality.
Recombinant sdAb–Fc fusion (heavy-chain) reagents
Genetic fusions of sdAbs to mammalian Fc domains produced in HEK cells to provide divalent reagents compatible with Fc-based detection and amplification systems.
Peptide elution reagent for tag-based affinity purification
Lyophilized peptide supplied with instructions for reconstitution to prepare native elution buffers for peptide-elutable selector resins; storage and handling guidance provided.
Mini centrifuge columns for small-volume resin handling
Disposable mini columns with internal filter for processing small volumes of bead-based resins in standard microcentrifuges.
Multiplexing blocker reagents
Protein mixtures containing sdAbs that bind common immunoglobulins to block cross-reactivity and enable multiplexed detection workflows.
Fluorophore-conjugated single-domain antibody reagents (single- and multi-dye)
Fluorescently labeled sdAb reagents with defined numbers of fluorophores at known positions available in single-fluorophore (quantitative) and multi-fluorophore formats for high-sensitivity imaging and super-resolution applications.
Affinity selector resins for tagged proteins (agarose and magnetic)
Covalently immobilized sdAbs on cross-linked agarose or magnetic beads for capture and purification of tagged proteins and fusions; oriented attachment reduces non-specific binding and preserves functionality.
Recombinant sdAb–Fc fusion (heavy-chain) reagents
Genetic fusions of sdAbs to mammalian Fc domains produced in HEK cells to provide divalent reagents compatible with Fc-based detection and amplification systems.
Peptide elution reagent for tag-based affinity purification
Lyophilized peptide supplied with instructions for reconstitution to prepare native elution buffers for peptide-elutable selector resins; storage and handling guidance provided.
Mini centrifuge columns for small-volume resin handling
Disposable mini columns with internal filter for processing small volumes of bead-based resins in standard microcentrifuges.
Multiplexing blocker reagents
Protein mixtures containing sdAbs that bind common immunoglobulins to block cross-reactivity and enable multiplexed detection workflows.
Services
Custom discovery projects including antigen design, immunization, PBMC-derived or synthetic library construction, tailored panning strategies, candidate sequencing and initial in vitro validation; delivery options range from nucleic acid/blood material to purified clones.
Expression and purification in bacterial and mammalian systems with services including codon optimization, construct design, clone screening, QC, scale-up, lyophilization, endotoxin removal and options for animal-free media.
Site-specific conjugation of sdAbs to fluorescent dyes and other labels using thiol-reactive chemistries, with control of labeling stoichiometry and compatibility with a broad range of dyes.
Custom discovery projects including antigen design, immunization, PBMC-derived or synthetic library construction, tailored panning strategies, candidate sequencing and initial in vitro validation; delivery options range from nucleic acid/blood material to purified clones.
Expression and purification in bacterial and mammalian systems with services including codon optimization, construct design, clone screening, QC, scale-up, lyophilization, endotoxin removal and options for animal-free media.
Site-specific conjugation of sdAbs to fluorescent dyes and other labels using thiol-reactive chemistries, with control of labeling stoichiometry and compatibility with a broad range of dyes.
Expertise Areas
- Single-domain antibody discovery and screening
- Library-based lead identification (phage and ribosome display)
- Affinity-based B-cell selection from PBMCs
- Site-specific fluorescent labeling for microscopy
Key Technologies
- Single-domain antibodies (sdAbs / nanobodies)
- Phage display
- Ribosome display
- Site-specific fluorophore conjugation with controlled stoichiometry
News & Updates
Announcement of an agreement granting a partner rights to evaluate the company's tag-based target labeling system across oncology and infectious disease indications in preclinical and clinical settings.
Announcement of an agreement granting a partner rights to evaluate the company's tag-based target labeling system across oncology and infectious disease indications in preclinical and clinical settings.