MD Biosciences
MD Biosciences is a preclinical CRO specializing in neuroscience, pain, and neurodegeneration research. With over 30 years of expertise, they offer tailored preclinical services including behavioral assessments, biomarker analysis, efficacy models, and large animal models such as pigs. Their mission is to advance scientific innovation and translational research to develop effective therapies for neurological diseases, pain, and wound healing. They focus on improving the clinical relevance of preclinical data, supporting drug development, and promoting animal welfare through responsible practices and rehoming programs.
Industries
Nr. of Employees
medium (51-250)
MD Biosciences
Minnesota City, Minnesota, United States, North America
Products
Validated Göttingen minipig post‑operative incisional pain model
A validated minipig model of post-operative incisional pain with behavioral, locomotor (open field), and intraepidermal nerve fiber histological endpoints for translational assessment of analgesics and local therapies.
Symptomatic neuroma porcine model
A clinically relevant symptomatic neuroma model in the pig for assessment of neuropathic pain and nerve repair interventions, with objective gait and weight-bearing endpoints.
Inflammatory Pain Models
Preclinical laboratory services offering a range of inflammatory pain models from acute inflammatory pain to chronic pain associated with arthritic conditions.
Translational Pig Models
Preclinical large species model services utilizing pigs to increase clinical translatability, featuring applications in neuroscience, electrophysiology, and pain models.
6OHDA Model of Parkinson's Disease
Unilateral lesion model utilizing 6-hydroxydopamine to damage the Nigro-Striatial pathway for evaluating neuroprotective therapies and pharmacological agents.
Patch Clamp Assay
Single cell electrophysiology live recording assay for evaluation of channel blockage and in-depth synaptic activity, featuring advanced electrophysiology recordings and analytical capabilities.
Validated Göttingen minipig post‑operative incisional pain model
A validated minipig model of post-operative incisional pain with behavioral, locomotor (open field), and intraepidermal nerve fiber histological endpoints for translational assessment of analgesics and local therapies.
Symptomatic neuroma porcine model
A clinically relevant symptomatic neuroma model in the pig for assessment of neuropathic pain and nerve repair interventions, with objective gait and weight-bearing endpoints.
Inflammatory Pain Models
Preclinical laboratory services offering a range of inflammatory pain models from acute inflammatory pain to chronic pain associated with arthritic conditions.
Translational Pig Models
Preclinical large species model services utilizing pigs to increase clinical translatability, featuring applications in neuroscience, electrophysiology, and pain models.
6OHDA Model of Parkinson's Disease
Unilateral lesion model utilizing 6-hydroxydopamine to damage the Nigro-Striatial pathway for evaluating neuroprotective therapies and pharmacological agents.
Patch Clamp Assay
Single cell electrophysiology live recording assay for evaluation of channel blockage and in-depth synaptic activity, featuring advanced electrophysiology recordings and analytical capabilities.
Services
End-to-end design and execution of efficacy studies using validated rodent and pig models with integrated behavioral, biomarker, and physiological endpoints.
Development and execution of porcine and minipig models for peripheral nerve injury, nerve repair, post-operative pain, neuroma, wound healing, and AKI to improve clinical translatability.
GLP-compliant toxicology studies and batch/lot release testing including OECD-GLP in vivo comparative activity models with GLP histopathology and electrophysiology readouts.
High-throughput multiplex immunoassays, ultra-sensitive single-plex protein assays, neurofilament light detection, ELISA, Western blot, and flow cytometry for preclinical and clinical sample analysis.
Implementation of standardized behavioral assays and scoring systems for pain, motor, cognitive, and affective function across species, including dynamic weight-bearing and spontaneous behavior scoring in pigs.
Cryosectioning, immunohistochemistry (including intraepidermal nerve fiber analysis), and GLP histopathology for tissue-based endpoint quantification.
End-to-end design and execution of efficacy studies using validated rodent and pig models with integrated behavioral, biomarker, and physiological endpoints.
Development and execution of porcine and minipig models for peripheral nerve injury, nerve repair, post-operative pain, neuroma, wound healing, and AKI to improve clinical translatability.
GLP-compliant toxicology studies and batch/lot release testing including OECD-GLP in vivo comparative activity models with GLP histopathology and electrophysiology readouts.
High-throughput multiplex immunoassays, ultra-sensitive single-plex protein assays, neurofilament light detection, ELISA, Western blot, and flow cytometry for preclinical and clinical sample analysis.
Implementation of standardized behavioral assays and scoring systems for pain, motor, cognitive, and affective function across species, including dynamic weight-bearing and spontaneous behavior scoring in pigs.
Cryosectioning, immunohistochemistry (including intraepidermal nerve fiber analysis), and GLP histopathology for tissue-based endpoint quantification.
Expertise Areas
- Preclinical efficacy study management
- Translational large-animal (porcine/minipig) modeling
- Pain, neuropathy, and neurodegeneration models
- Behavioral neuroscience and functional endpoints
Key Technologies
- Multiplex immunoassays
- Ultra-sensitive protein assays (femtogram-level)
- Neurofilament light biomarker assays
- Immunoassays (ELISA) and Western blot