MB Research Laboratories
MB Research Laboratories is a trusted contract research organization (CRO) based in Pennsylvania, specializing in toxicology, safety evaluation, and regulatory testing services since 1972. With over 50 years of experience, they provide GLP-compliant in vivo and in vitro toxicological testing for industries including pharmaceuticals, biotechnology, medical devices, agrochemicals, and government agencies. They are pioneers in non-animal testing methods, offering a comprehensive suite of regulatory toxicology studies tailored to meet regulatory and product development needs, with a focus on high quality and rapid turnaround. Their expertise extends to preclinical toxicology, classification of products, and compliance with USP, ISO, and FDA standards.
Industries
Nr. of Employees
small (1-50)
MB Research Laboratories
Services
Laboratory execution of guideline-based assays to support regulatory submissions across OECD, EPA/OCSPP, ISO, DOT, CPSC and other frameworks.
In vitro, ex vivo and in vivo assays for ocular and dermal irritation/corrosion and sensitization, including reconstructed tissue models, ex vivo corneal assays and egg CAM methods.
Suite of ISO 10993-aligned assays (cytotoxicity, sensitization, irritation, implantation, systemic toxicity, pyrogenicity, genotoxicity) to support premarket evaluation and product release.
Standardized acute toxicity studies covering oral, dermal, inhalation, eye and dermal irritation and skin sensitization endpoints required for EPA/FIFRA/TSCA evaluations.
Bacterial reverse mutation testing with and without metabolic activation to identify mutagenic potential of test articles.
Bespoke study design including customized time points, endpoints, flow cytometry and ELISA analyses; delivered as GLP or non-GLP services.
Laboratory execution of guideline-based assays to support regulatory submissions across OECD, EPA/OCSPP, ISO, DOT, CPSC and other frameworks.
In vitro, ex vivo and in vivo assays for ocular and dermal irritation/corrosion and sensitization, including reconstructed tissue models, ex vivo corneal assays and egg CAM methods.
Suite of ISO 10993-aligned assays (cytotoxicity, sensitization, irritation, implantation, systemic toxicity, pyrogenicity, genotoxicity) to support premarket evaluation and product release.
Standardized acute toxicity studies covering oral, dermal, inhalation, eye and dermal irritation and skin sensitization endpoints required for EPA/FIFRA/TSCA evaluations.
Bacterial reverse mutation testing with and without metabolic activation to identify mutagenic potential of test articles.
Bespoke study design including customized time points, endpoints, flow cytometry and ELISA analyses; delivered as GLP or non-GLP services.
Expertise Areas
- Regulatory toxicology testing and guideline execution
- In vitro and alternative method (NAM) development and validation
- Eye and skin safety assessment using reconstructed tissues and ex vivo models
- Biocompatibility evaluation for medical devices (ISO 10993 series)
Key Technologies
- Ex vivo corneal opacity and permeability assays (BCOP-style)
- Ex vivo porcine corneal assay with extended culture
- Reconstructed human cornea-like epithelium assays
- Reconstructed human epidermis assays for irritation and sensitization
News & Updates
An overview of the Buehler skin sensitization test, OECD TG 406, and its regulatory relevance.
Details about the Hen’s Egg Test on the Chorioallantoic Membrane (HET-CAM) as an alternative to traditional eye irritation tests.
An explanation of the OECD TG 439 guideline for in vitro skin irritation testing.
Introduction to the Porcine Cornea Opacity/Reversibility Assay (PorCORA) as an alternative testing protocol.
MB Research has sponsored an award for postdoctoral students in the field of in vitro and alternative methods since 2010.
An overview of the Buehler skin sensitization test, OECD TG 406, and its regulatory relevance.
Details about the Hen’s Egg Test on the Chorioallantoic Membrane (HET-CAM) as an alternative to traditional eye irritation tests.
An explanation of the OECD TG 439 guideline for in vitro skin irritation testing.
Introduction to the Porcine Cornea Opacity/Reversibility Assay (PorCORA) as an alternative testing protocol.
MB Research has sponsored an award for postdoctoral students in the field of in vitro and alternative methods since 2010.