ingenious targeting laboratory
ingenious targeting laboratory is a leading global provider of custom genetically modified mouse, rat, and rabbit models, with over 30 years of experience in animal model generation. They specialize in creating precise genetic models for research across various fields including immunology, neuroscience, oncology, metabolic disorders, and infectious diseases. They utilize advanced technologies such as CRISPR, gene replacement, and humanized models to deliver high-quality, tailored animal models that accelerate biomedical research. Their models support studies in cancer, neurodegeneration, immunotherapy, and infectious diseases, providing reliable platforms for testing new therapies and understanding disease mechanisms.
Industries
Nr. of Employees
medium (51-250)
ingenious targeting laboratory
Ronkonkoma, New York, United States, North America
Products
Catalog repository of genetically engineered mouse models
A catalog of study-ready genetically engineered mouse strains including reporter knockins, recombinase knockins, conventional and conditional knockouts, humanized and immunodeficient strains available on consistent genetic backgrounds for immediate purchase and shipment.
Double immune-checkpoint humanized mouse strains (catalog)
Research-ready double immune-checkpoint humanized mouse strains (paired human immune-checkpoint genes) available on common genetic backgrounds for immuno-oncology and drug efficacy studies.
Breeding planner (software tool)
Web-based breeding-planner that models breeding timelines, predicts time and cost of projects based on strain breeding performance and facility operating costs, and visualizes breeding outcomes.
Catalog repository of genetically engineered mouse models
A catalog of study-ready genetically engineered mouse strains including reporter knockins, recombinase knockins, conventional and conditional knockouts, humanized and immunodeficient strains available on consistent genetic backgrounds for immediate purchase and shipment.
Double immune-checkpoint humanized mouse strains (catalog)
Research-ready double immune-checkpoint humanized mouse strains (paired human immune-checkpoint genes) available on common genetic backgrounds for immuno-oncology and drug efficacy studies.
Breeding planner (software tool)
Web-based breeding-planner that models breeding timelines, predicts time and cost of projects based on strain breeding performance and facility operating costs, and visualizes breeding outcomes.
Services
Contract design and production of knockout, conditional, knockin, humanized and targeted transgenic models in mice, rats and rabbits, delivered as germline-confirmed founders or lines.
Services enabling genomic edits up to ~200 kb, including whole-gene deletions, replacements and human gene integration for full-gene humanization.
Targeted integration of transgenes into safe-harbor loci for predictable expression and reduced position-effect variability.
Targeted ES cell generation, screening and supply of FLP-expressing ES cell lines or targeted ES clones to streamline selection cassette excision and support chimera production.
Design and implementation of multi-state inducible or reversible alleles (tetracycline-regulated systems) to enable knockout, conditional rescue, inducible overexpression or knockdown from a single targeted locus.
Pronuclear injection, embryo electroporation/microinjection, embryo transfer and founder screening services to generate animals from constructs or targeted ES cell clones.
Contract design and production of knockout, conditional, knockin, humanized and targeted transgenic models in mice, rats and rabbits, delivered as germline-confirmed founders or lines.
Services enabling genomic edits up to ~200 kb, including whole-gene deletions, replacements and human gene integration for full-gene humanization.
Targeted integration of transgenes into safe-harbor loci for predictable expression and reduced position-effect variability.
Targeted ES cell generation, screening and supply of FLP-expressing ES cell lines or targeted ES clones to streamline selection cassette excision and support chimera production.
Design and implementation of multi-state inducible or reversible alleles (tetracycline-regulated systems) to enable knockout, conditional rescue, inducible overexpression or knockdown from a single targeted locus.
Pronuclear injection, embryo electroporation/microinjection, embryo transfer and founder screening services to generate animals from constructs or targeted ES cell clones.
Expertise Areas
- Custom genetically engineered animal models
- Full-gene humanization and large-insert gene replacement
- Immune-checkpoint humanized models for immuno-oncology
- ES cell targeting and engineered ES cell line workflows
Key Technologies
- Large-insert targeting (BAC/fosmid) and single-step gene replacement
- Homologous recombination in embryonic stem cells
- Embryo microinjection and blastocyst injection
- CRISPR/Cas systems, high-fidelity nucleases and electroporation delivery
News & Updates
Read the latest updates and summaries of mouse model research.
Research on BTG1 mutation and its role in B cell malignancy.
Study on NUP62's role in neurodegenerative disease.
Research on a transgenic mouse model for optogenetics and imaging.
Over 2,800 Projects Completed
Successfully completed over 2,800 animal model projects since inception.
Published in Major Journals
Models have been featured in over 600 publications including Science, Nature, and Cell.
Read the latest updates and summaries of mouse model research.
Research on BTG1 mutation and its role in B cell malignancy.
Study on NUP62's role in neurodegenerative disease.
Research on a transgenic mouse model for optogenetics and imaging.
Over 2,800 Projects Completed
Successfully completed over 2,800 animal model projects since inception.
Published in Major Journals
Models have been featured in over 600 publications including Science, Nature, and Cell.