Huang Lab
Academic translational research laboratory focused on tumor immunology and immunotherapy for pediatric and adolescent/young adult cancers. Core activities include intravital and fluorescence imaging of immune–tumor interactions, preclinical development of cell- and vaccine-based immunotherapies, monoclonal antibody discovery, mechanistic studies of metastasis and immune checkpoints, and translation of preclinical findings into IND-enabling studies and clinical trials. The laboratory is integrated with an ACGME-accredited pediatric hematology/oncology fellowship program and hospital clinical infrastructure.
Industries
Nr. of Employees
small (1-50)
Huang Lab
Wolstein Research Building Room 6401, 2103 Cornell Road, Cleveland, OH 44106-7288, USA
Products
Intravital 2-Photon Laser Scanning Microscopy Platform
A microscopy platform for real-time, high-resolution imaging of immune cell behavior and interactions in living tissues.
Cellular Immunotherapy Research and Development
Research focused on developing and improving cellular immunotherapies targeting pediatric and adolescent cancers by studying immune cell trafficking and tumor microenvironment.
Tumor Microenvironment and Immune Cell Interaction Studies
Investigations into how the tumor microenvironment influences immune cell recruitment, tolerance, and function in cancer progression and therapy.
Preclinical Animal Models for Immunotherapy Evaluation
Use of syngeneic and xenograft mouse models to study immune cell behavior and test immunotherapeutic approaches in pediatric cancer research.
Chemokine and Immune Cell Recruitment Research
Research on the role of chemokines in guiding immune cell recruitment and activation during immune responses and cancer immunotherapy.
Intravital 2-Photon Laser Scanning Microscopy Platform
A microscopy platform for real-time, high-resolution imaging of immune cell behavior and interactions in living tissues.
Cellular Immunotherapy Research and Development
Research focused on developing and improving cellular immunotherapies targeting pediatric and adolescent cancers by studying immune cell trafficking and tumor microenvironment.
Tumor Microenvironment and Immune Cell Interaction Studies
Investigations into how the tumor microenvironment influences immune cell recruitment, tolerance, and function in cancer progression and therapy.
Preclinical Animal Models for Immunotherapy Evaluation
Use of syngeneic and xenograft mouse models to study immune cell behavior and test immunotherapeutic approaches in pediatric cancer research.
Chemokine and Immune Cell Recruitment Research
Research on the role of chemokines in guiding immune cell recruitment and activation during immune responses and cancer immunotherapy.
Services
Design and preclinical testing of vaccine, antibody and cell-based immunotherapies using intravital and fluorescence imaging alongside murine tumor and immune models.
Translational expertise to inform clinical trial concepts and protocols in pediatric and AYA oncology based on mechanistic preclinical immune data and regulatory collaborations.
ACGME-accredited three-year pediatric hematology/oncology fellowship providing supervised inpatient and outpatient clinical rotations, laboratory rotations (transfusion, coagulation, hematopathology), elective research time, continuity clinic, didactic series and mentored, thesis-driven research with protected research years.
Design and preclinical testing of vaccine, antibody and cell-based immunotherapies using intravital and fluorescence imaging alongside murine tumor and immune models.
Translational expertise to inform clinical trial concepts and protocols in pediatric and AYA oncology based on mechanistic preclinical immune data and regulatory collaborations.
ACGME-accredited three-year pediatric hematology/oncology fellowship providing supervised inpatient and outpatient clinical rotations, laboratory rotations (transfusion, coagulation, hematopathology), elective research time, continuity clinic, didactic series and mentored, thesis-driven research with protected research years.
Expertise Areas
- Tumor immunology
- Intravital and fluorescence microscopy
- Pediatric and AYA oncology translational research
- Cell-based immunotherapy (adoptive T and NK cells)
Key Technologies
- Intravital multiphoton microscopy
- Fluorescence microscopy
- In vivo murine tumor models
- Ex vivo T-cell activation and expansion
News & Updates
Awarded a $1.35M, 3-year grant to support immune-based clinical trials targeting metastatic pulmonary osteosarcoma.
Preclinical data and a clinical trial concept from the laboratory contributed to an industry partner's IND approval and orphan-drug designation for a TGF-beta receptor kinase inhibitor in osteosarcoma.
Ongoing and past funding from NCI/NIH mechanisms, St. Baldrick's Foundation, Alex's Lemonade Stand Foundation, Hyundai Hope-on-Wheels and private foundations supporting basic and translational projects.
Trainees associated with the program have received trainee awards including FRAP awards and foundation postdoctoral fellowships.
Program alumni have progressed to clinical fellowships and academic appointments (examples on alumni page include appointments at children's hospitals and academic institutions).
Lecture recordings, conference presentations and outreach videos documenting laboratory research and program activities are available via hosted video channels and conference links.
Awarded a $1.35M, 3-year grant to support immune-based clinical trials targeting metastatic pulmonary osteosarcoma.
Preclinical data and a clinical trial concept from the laboratory contributed to an industry partner's IND approval and orphan-drug designation for a TGF-beta receptor kinase inhibitor in osteosarcoma.
Ongoing and past funding from NCI/NIH mechanisms, St. Baldrick's Foundation, Alex's Lemonade Stand Foundation, Hyundai Hope-on-Wheels and private foundations supporting basic and translational projects.
Trainees associated with the program have received trainee awards including FRAP awards and foundation postdoctoral fellowships.
Program alumni have progressed to clinical fellowships and academic appointments (examples on alumni page include appointments at children's hospitals and academic institutions).
Lecture recordings, conference presentations and outreach videos documenting laboratory research and program activities are available via hosted video channels and conference links.