HTD Biosystems
HTD Biosystems is a private biotech company based in Livermore, California, specializing in drug development, formulation, and characterization services for biopharmaceuticals, vaccines, liposomal systems, and nanoparticles. They focus on accelerating drug development from discovery to the clinic through innovative solutions, flexible collaboration, and advanced analytical techniques.
Industries
Nr. of Employees
small (1-50)
HTD Biosystems
Pleasanton, California, United States, North America
Products
High-throughput formulation optimization platform
Algorithm-driven platform for rapid formulation screening that uses design of experiments and modeling approaches (including machine learning/AI) to identify stable, pharmaceutically acceptable formulations.
High-throughput formulation optimization platform
Algorithm-driven platform for rapid formulation screening that uses design of experiments and modeling approaches (including machine learning/AI) to identify stable, pharmaceutically acceptable formulations.
Services
Protein formulation development
Contract formulation development for biologics (monoclonal and bispecific antibodies, ADCs, enzymes, peptides, nucleic acids) across liquid, frozen and lyophilized presentations; excipient selection, co-formulation and high-concentration strategies.
Lyophilization services and cycle optimization
Development and optimization of lyophilization cycles, analytical assessment of lyophilized cake properties, residual moisture testing, and pilot-scale lyophilization with transfer to manufacturing.
Protein characterization and analytical testing
Bioanalytical services to determine identity, purity, content, stability and activity of protein products using orthogonal and high-throughput methods (DSF, DLS, HPLC, UV spectroscopy, FlowCam, SEC).
Liposomal and LNP formulation development
Design and development of liposomal vaccines and lipid nanoparticle formulations, including control of size, payload encapsulation and properties for targeted delivery.
Vaccine formulation and immunogenicity testing
Formulation and small-batch production of vaccine candidates across multiple platforms, with in vitro and in vivo immunogenicity and safety testing support (e.g., ELISA, animal models).
GLP tox-lot manufacturing and aseptic fill–finish
GLP-compliant manufacturing of parenteral products for preclinical studies including aseptic fill–finish, sterilization and packaging workflows to support toxicology programs.
Protein formulation development
Contract formulation development for biologics (monoclonal and bispecific antibodies, ADCs, enzymes, peptides, nucleic acids) across liquid, frozen and lyophilized presentations; excipient selection, co-formulation and high-concentration strategies.
Lyophilization services and cycle optimization
Development and optimization of lyophilization cycles, analytical assessment of lyophilized cake properties, residual moisture testing, and pilot-scale lyophilization with transfer to manufacturing.
Protein characterization and analytical testing
Bioanalytical services to determine identity, purity, content, stability and activity of protein products using orthogonal and high-throughput methods (DSF, DLS, HPLC, UV spectroscopy, FlowCam, SEC).
Liposomal and LNP formulation development
Design and development of liposomal vaccines and lipid nanoparticle formulations, including control of size, payload encapsulation and properties for targeted delivery.
Vaccine formulation and immunogenicity testing
Formulation and small-batch production of vaccine candidates across multiple platforms, with in vitro and in vivo immunogenicity and safety testing support (e.g., ELISA, animal models).
GLP tox-lot manufacturing and aseptic fill–finish
GLP-compliant manufacturing of parenteral products for preclinical studies including aseptic fill–finish, sterilization and packaging workflows to support toxicology programs.
Expertise Areas
- Protein formulation development
- Lyophilization and freeze-drying cycle optimization
- Liposomal and lipid nanoparticle (LNP) formulation
- Vaccine formulation and preclinical testing
Key Technologies
- Differential scanning calorimetry (DSC)
- Differential scanning fluorimetry (DSF / nDSF)
- Dynamic light scattering (DLS)
- Flow imaging microscopy (FlowCam)