Hesperos, Inc.
Hesperos is a leading company in human-on-a-chip research, providing advanced multi-organ microphysiological systems for drug discovery, disease modeling, and safety testing. With over 20 years of expertise, they develop physiologically realistic models that offer unprecedented preclinical insights, aiming to accelerate drug development, reduce animal testing, and target both rare and common diseases.
Industries
Nr. of Employees
small (1-50)
Products
Configurable multi-organ microphysiological platform
An integrated, reconfigurable in vitro platform that links multiple human tissue modules in a low-volume, serum-free, pumpless recirculating system with noninvasive functional readouts for preclinical testing and translational studies.
Configurable multi-organ microphysiological platform
An integrated, reconfigurable in vitro platform that links multiple human tissue modules in a low-volume, serum-free, pumpless recirculating system with noninvasive functional readouts for preclinical testing and translational studies.
Services
Safety & Efficacy Testing using multi-organ microphysiological systems
Contract research services to evaluate compound efficacy, off-target toxicity, metabolite effects, and therapeutic index using configurable multi-organ in vitro platforms.
Custom model development (2–5+ organ configurations)
Design and build of bespoke multi-organ models incorporating selected organ and barrier tissues, patient-derived or iPSC cells, and bespoke assay metrics for specific research questions.
PK/PD and PBPK modeling coupled to experimental data
Computational modeling services that combine experimental concentration measurements and fluid dynamics to derive PK-PD relationships and extrapolate in vitro results toward in vivo outcomes.
Analytical bioanalysis (HPLC-MS)
Analytical measurement of parent compounds and metabolites in system media and compartments using HPLC–mass spectrometry to support PK profiling and metabolite identification.
Safety & Efficacy Testing using multi-organ microphysiological systems
Contract research services to evaluate compound efficacy, off-target toxicity, metabolite effects, and therapeutic index using configurable multi-organ in vitro platforms.
Custom model development (2–5+ organ configurations)
Design and build of bespoke multi-organ models incorporating selected organ and barrier tissues, patient-derived or iPSC cells, and bespoke assay metrics for specific research questions.
PK/PD and PBPK modeling coupled to experimental data
Computational modeling services that combine experimental concentration measurements and fluid dynamics to derive PK-PD relationships and extrapolate in vitro results toward in vivo outcomes.
Analytical bioanalysis (HPLC-MS)
Analytical measurement of parent compounds and metabolites in system media and compartments using HPLC–mass spectrometry to support PK profiling and metabolite identification.
Expertise Areas
- Microphysiological systems development
- In vitro disease and translational modeling
- Preclinical safety and efficacy testing using linked tissue platforms
- PK/PD, PBPK and translational computational modeling
Key Technologies
- Pumpless rocking microfluidics
- Microelectrode arrays (MEA)
- Microcantilever force sensors
- Induced pluripotent stem cell (iPSC) differentiation