Explora Biotech
Explora Bioscience Srl is a pioneering partner in the development and preclinical validation of advanced therapy medicinal products (ATMPs). They offer comprehensive services from study design to validation, supporting clients with gene therapy, somatic cells, tissue engineering, and regenerative medicine. Their mission is to facilitate the safe and effective development of next-generation ATMPs, ensuring compliance with regulatory standards and biosecurity, while providing innovative solutions for complex biomedical challenges.
Industries
Nr. of Employees
small (1-50)
Explora Biotech
Products
AMCARE (cardiac regeneration preclinical study)
Project supporting development of biodegradable elastic cardiac patches and delivery methods; included development of an ischemia/reperfusion swine model and catheter-based delivery approaches to evaluate functional recovery post-MI.
THE GRAIL (atherosclerosis model and stent testing)
Project delivering an atherosclerosis model based on immune-mediated endothelial injury to evaluate bioresorbable vascular devices while avoiding mechanical barotrauma artifacts.
DRIVE (diabetes and islet transplantation models)
Project focused on developing and validating models and encapsulation approaches to improve pancreatic islet transplantation outcomes; included streptomycin-induced diabetes models and clinically-reflective islet implantation sites in swine.
AMCARE (cardiac regeneration preclinical study)
Project supporting development of biodegradable elastic cardiac patches and delivery methods; included development of an ischemia/reperfusion swine model and catheter-based delivery approaches to evaluate functional recovery post-MI.
THE GRAIL (atherosclerosis model and stent testing)
Project delivering an atherosclerosis model based on immune-mediated endothelial injury to evaluate bioresorbable vascular devices while avoiding mechanical barotrauma artifacts.
DRIVE (diabetes and islet transplantation models)
Project focused on developing and validating models and encapsulation approaches to improve pancreatic islet transplantation outcomes; included streptomycin-induced diabetes models and clinically-reflective islet implantation sites in swine.
Services
GLP-grade cell culture services including formulation preparation, cell conditioning, tissue culture and controlled cell manipulation for preclinical implantation studies.
Design and execution of physiological and pathological animal models across mice, rats, rabbits and pigs to assess safety and efficacy of ATMPs and devices.
Molecular biology, sequencing, proteomics and histology services including DNA genotyping, cDNA sequencing, real-time gene expression, PAGE-MS/MS workflows, histological staining, IHC/IF and image analysis.
Quality management, GLP implementation, ethical review coordination, biosecurity screening and facility accreditation support to meet European and international regulatory requirements for preclinical work.
GLP-grade cell culture services including formulation preparation, cell conditioning, tissue culture and controlled cell manipulation for preclinical implantation studies.
Design and execution of physiological and pathological animal models across mice, rats, rabbits and pigs to assess safety and efficacy of ATMPs and devices.
Molecular biology, sequencing, proteomics and histology services including DNA genotyping, cDNA sequencing, real-time gene expression, PAGE-MS/MS workflows, histological staining, IHC/IF and image analysis.
Quality management, GLP implementation, ethical review coordination, biosecurity screening and facility accreditation support to meet European and international regulatory requirements for preclinical work.
Expertise Areas
- Preclinical study design and execution for ATMPs
- In vivo disease and implantation models (rodent to swine)
- ATMP cell culture and formulation
- Molecular assays and sequencing
Key Technologies
- cDNA library construction and sequencing
- Real-time PCR (qPCR) gene expression analysis
- DNA genotyping
- 1D and 2D polyacrylamide gel electrophoresis (PAGE)
News & Updates
Development of an acute myocardial infarction model for cardiac regeneration, demonstrating significant improvements in heart function post-treatment.
Establishment of a continuous feedback design review process for developing bioresorbable stents for blood vessel repair.
Development of a swine model for pancreatic islet transplantation to improve diabetes treatment.
Supporting high-quality experimental design and delivery with services like histology, microscopy, and tissue characterization.
Development of an acute myocardial infarction model for cardiac regeneration, demonstrating significant improvements in heart function post-treatment.
Establishment of a continuous feedback design review process for developing bioresorbable stents for blood vessel repair.
Development of a swine model for pancreatic islet transplantation to improve diabetes treatment.
Supporting high-quality experimental design and delivery with services like histology, microscopy, and tissue characterization.