EpiBone
EpiBone is dedicated to transforming skeletal repair through groundbreaking research and engineering. Their mission is to help people live happier and more active lives by regrowing bone and cartilage using stem cells, without the need for artificial grafts or implants. They focus on personalized, lifelong tissue growth that integrates seamlessly with the body, aiming to address the root causes of skeletal conditions and reduce long-term disability.
Industries
Nr. of Employees
small (1-50)
Patents
Products
Tissue-engineered patient-specific autologous bone graft for craniofacial reconstruction
A CT-customized, tissue-engineered autologous bone graft produced from a patient's adipose-derived stem cells and grown on an osteogenic scaffold for facial bone defects.
Allogeneic tissue-engineered osteochondral implant (osteochondral plug)
An osteochondral plug composed of condensed mesenchymal cells on a bone scaffold with an engineered cartilage layer, cultivated under cyclical mechanical loading and perfusion to treat high-grade cartilage lesions.
Allogeneic injectable cartilage filler
An injectable cartilage product consisting of primed condensed mesenchymal cells combined with a hydrogel carrier, intended for low-grade cartilage lesions without bone involvement; components can be stored for scheduling flexibility.
tissue-engineered
Our facial bone product is indicated for craniofacial defects resulting from trauma, congenital defect or degenerative bone disease. It is customized for patients via a CT scan so that precise anatomical shape can be cultivated, and with stem cells extracted from patients’ abdominal fat.
tissue-engineered osteochondral autograft
Our EB-OC product is an allogenic, tissue-engineered osteochondral plug for treating high-grade cartilage lesions in healthy joints, composed of condensed mesenchymal cells from donor bone marrow encapsulated in hydrogel.
Personalized Bone
Personalized bone and cartilage grown from stem cells using a proprietary bioreactor, designed to provide a natural, living implant tailored to precise anatomical shapes.
Tissue-engineered patient-specific autologous bone graft for craniofacial reconstruction
A CT-customized, tissue-engineered autologous bone graft produced from a patient's adipose-derived stem cells and grown on an osteogenic scaffold for facial bone defects.
Allogeneic tissue-engineered osteochondral implant (osteochondral plug)
An osteochondral plug composed of condensed mesenchymal cells on a bone scaffold with an engineered cartilage layer, cultivated under cyclical mechanical loading and perfusion to treat high-grade cartilage lesions.
Allogeneic injectable cartilage filler
An injectable cartilage product consisting of primed condensed mesenchymal cells combined with a hydrogel carrier, intended for low-grade cartilage lesions without bone involvement; components can be stored for scheduling flexibility.
tissue-engineered
Our facial bone product is indicated for craniofacial defects resulting from trauma, congenital defect or degenerative bone disease. It is customized for patients via a CT scan so that precise anatomical shape can be cultivated, and with stem cells extracted from patients’ abdominal fat.
tissue-engineered osteochondral autograft
Our EB-OC product is an allogenic, tissue-engineered osteochondral plug for treating high-grade cartilage lesions in healthy joints, composed of condensed mesenchymal cells from donor bone marrow encapsulated in hydrogel.
Personalized Bone
Personalized bone and cartilage grown from stem cells using a proprietary bioreactor, designed to provide a natural, living implant tailored to precise anatomical shapes.
Services
End-to-end manufacturing of anatomically shaped bone and cartilage grafts using patient imaging, stem-cell processing, scaffold/hydrogel systems, and bioreactor culture.
Large-animal implantation studies and translational research to validate engineered tissue function prior to clinical trials.
Designs and conducts early-phase clinical trials for tissue-engineered skeletal products, including IND-enabled studies.
End-to-end manufacturing of anatomically shaped bone and cartilage grafts using patient imaging, stem-cell processing, scaffold/hydrogel systems, and bioreactor culture.
Large-animal implantation studies and translational research to validate engineered tissue function prior to clinical trials.
Designs and conducts early-phase clinical trials for tissue-engineered skeletal products, including IND-enabled studies.
Expertise Areas
- Tissue engineering for bone and cartilage
- Personalized/ patient-specific graft manufacturing
- Bioreactor development and bioprocessing
- Stem cell sourcing and processing
Key Technologies
- Custom bioreactor systems
- CT-based 3D anatomical modeling
- Adipose-derived stem cell isolation
- Mesenchymal condensation
News & Updates
Proceedings of the National Academy of Sciences, Feb 2010
Proceedings of the National Academy of Sciences, May 2014
Science Translational Medicine, Jun 2016
Bone tissue engineering, Springer, Mar 2022
ACS Biomaterials Science & Engineering, Nov 2022
Journal of Clinical Pathways, Jun 2024
Proceedings of the National Academy of Sciences, Feb 2010
Proceedings of the National Academy of Sciences, May 2014
Science Translational Medicine, Jun 2016
Bone tissue engineering, Springer, Mar 2022
ACS Biomaterials Science & Engineering, Nov 2022
Journal of Clinical Pathways, Jun 2024