EnClear Therapies
EnClear Therapies aims to improve and extend the lives of patients suffering from CNS diseases through precision dosing. They are building an integrated neurotechnology business utilizing their proprietary EnTrega CSF Platform to create patient-focused opportunities, initially launching into neuro-oncology and expanding into neurodegenerative, lysosomal storage, and autoimmune diseases through partnerships.
Industries
Nr. of Employees
small (1-50)
Products
CSF delivery and monitoring platform (in development)
A platform that provides controlled, continuous, and personalized delivery of therapeutics via CSF combined with monitoring capabilities and integrated ML/AI for dosing optimization; intended to improve CNS distribution and enable outpatient administration.
CSF delivery and monitoring platform (in development)
A platform that provides controlled, continuous, and personalized delivery of therapeutics via CSF combined with monitoring capabilities and integrated ML/AI for dosing optimization; intended to improve CNS distribution and enable outpatient administration.
Services
Partnerships for modality development and dose optimization
Collaborative development agreements to apply CSF delivery and monitoring to externally developed therapeutics (small molecules, ASOs, AAVs, siRNAs, enzyme therapies) and to optimize dosing profiles.
Preclinical evaluation of CNS distribution and delivery
Preclinical studies and testing to characterize CNS drug distribution and compare CSF-based delivery to standard intrathecal/intraventricular approaches.
Partnerships for modality development and dose optimization
Collaborative development agreements to apply CSF delivery and monitoring to externally developed therapeutics (small molecules, ASOs, AAVs, siRNAs, enzyme therapies) and to optimize dosing profiles.
Preclinical evaluation of CNS distribution and delivery
Preclinical studies and testing to characterize CNS drug distribution and compare CSF-based delivery to standard intrathecal/intraventricular approaches.
Expertise Areas
- CSF-based drug delivery
- Precision dosing and personalized CNS therapeutics
- Neuro-oncology (leptomeningeal carcinomatosis)
- Preclinical CNS pharmacokinetics and biodistribution
Key Technologies
- CSF delivery systems
- Closed-loop control systems
- Machine learning / AI-driven dosing optimization
- Intrathecal and intraventricular infusion techniques