DendroPharm
DendroPharm GmbH is a Berlin-based company specializing in the development and manufacturing of nanocarriers, drug delivery systems, and pharmaceutical excipients. The company focuses on innovative therapies, custom synthesis, formulation development, and contract manufacturing, with a strong emphasis on nanotechnology and bio-compatible dendritic core-multishell nanocarriers. It aims to improve drug bioavailability, reduce side effects, and develop new drug delivery systems for human and veterinary medicine. DendroPharm collaborates with research institutions and industry partners, and is certified according to ISO 9001:2015 and GMP standards.
Industries
Products
Amphiphilic skin-penetrating nanocarrier
Amphiphilic dendritic core–multishell nanocarrier designed to enhance transdermal penetration of both lipophilic and hydrophilic compounds and increase apparent solubility and bioavailability.
pH-cleavable tumor-accumulating nanocarrier
Core–multishell nanocarrier series engineered for selective accumulation in tumor tissue with pH-dependent drug release enabling controlled payload release in the tumor microenvironment.
Sulfated multivalent anti-inflammatory nanomaterial
Highly sulfated multivalent nanomaterial with strong binding to selectins and reported anti-inflammatory and antithrombotic activity functioning as a heparin-analogue scaffold.
Amphiphilic skin-penetrating nanocarrier
Amphiphilic dendritic core–multishell nanocarrier designed to enhance transdermal penetration of both lipophilic and hydrophilic compounds and increase apparent solubility and bioavailability.
pH-cleavable tumor-accumulating nanocarrier
Core–multishell nanocarrier series engineered for selective accumulation in tumor tissue with pH-dependent drug release enabling controlled payload release in the tumor microenvironment.
Sulfated multivalent anti-inflammatory nanomaterial
Highly sulfated multivalent nanomaterial with strong binding to selectins and reported anti-inflammatory and antithrombotic activity functioning as a heparin-analogue scaffold.
Services
Contract manufacturing of GMP test samples and small batches
GMP-compliant production of clinical test samples and small-scale batches (semi-solid and non-sterile liquid formulations) including stability studies with GMP analytics.
Synthesis of tailor-made nanocarriers and specialty polymers
Custom synthesis of functionalized polymers and building-block based core–multishell nanocarriers tailored to customer application requirements.
Analytical characterization and method development
Analytical services including chromatographic analysis, light-scattering, spectroscopy, HPLC method development and validation for nanocarriers and formulations.
Formulation development and penetration testing
Development of transdermal and topical formulations and in vitro penetration/release testing using Franz diffusion cells and multiple skin and mucosal models.
Contract purification and downstream processing for nanomaterials
Purification services (e.g., ultrafiltration) and downstream processing tailored to nanomaterial production.
Stability studies and controlled-environment testing
Conduct of stability studies under controlled conditions and accelerated/stress testing following ICH principles.
Contract manufacturing of GMP test samples and small batches
GMP-compliant production of clinical test samples and small-scale batches (semi-solid and non-sterile liquid formulations) including stability studies with GMP analytics.
Synthesis of tailor-made nanocarriers and specialty polymers
Custom synthesis of functionalized polymers and building-block based core–multishell nanocarriers tailored to customer application requirements.
Analytical characterization and method development
Analytical services including chromatographic analysis, light-scattering, spectroscopy, HPLC method development and validation for nanocarriers and formulations.
Formulation development and penetration testing
Development of transdermal and topical formulations and in vitro penetration/release testing using Franz diffusion cells and multiple skin and mucosal models.
Contract purification and downstream processing for nanomaterials
Purification services (e.g., ultrafiltration) and downstream processing tailored to nanomaterial production.
Stability studies and controlled-environment testing
Conduct of stability studies under controlled conditions and accelerated/stress testing following ICH principles.
Expertise Areas
- Nanocarrier design and synthesis
- Transdermal and mucosal drug delivery
- Formulation development for semi-solid and topical products
- Analytical method development and characterization of nanomaterials
Key Technologies
- Core–multishell dendritic nanocarriers
- Building-block synthetic design
- Amphiphilic nanocarriers for skin penetration
- pH-cleavable nanocarriers for tumor targeting