Codexis Inc.
Codexis is a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance high-performance enzymes. The company focuses on enzymatic manufacturing of small interference ribonucleic acid (siRNA) therapeutics and has engineered enzymes for major pharmaceutical products. It aims to revolutionize enzyme performance and expand the development of RNAi therapeutics, with a strong culture of innovation and technological advancement.
Industries
Nr. of Employees
medium (51-250)
Codexis Inc.
200 Penobscot Drive, Redwood City, CA 94063, USA
Patents
Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US-12312609-B2
View Details
Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US-12312609-B2
View DetailsProducts
Enzyme screening kits and panels
Pre-configured enzyme panels and screening kits designed to evaluate enzyme activity and identify lead candidates for process development.
Machine-learning protein engineering software suite
Computational tools for analyzing sequence-activity data, predicting mutation impacts, designing combinatorial libraries, and visualizing large protein engineering datasets.
Enzymatic oligonucleotide synthesis platform
A manufacturing platform that implements enzyme-catalyzed oligonucleotide synthesis workflows and ligation-based assembly options to produce siRNA and other oligonucleotides.
Engineered enzymes for NGS library preparation and mRNA production
Engineered ligases and RNA polymerases designed to improve efficiency and reduce byproducts in NGS library prep and mRNA synthesis workflows.
Enzyme screening kits and panels
Pre-configured enzyme panels and screening kits designed to evaluate enzyme activity and identify lead candidates for process development.
Machine-learning protein engineering software suite
Computational tools for analyzing sequence-activity data, predicting mutation impacts, designing combinatorial libraries, and visualizing large protein engineering datasets.
Enzymatic oligonucleotide synthesis platform
A manufacturing platform that implements enzyme-catalyzed oligonucleotide synthesis workflows and ligation-based assembly options to produce siRNA and other oligonucleotides.
Engineered enzymes for NGS library preparation and mRNA production
Engineered ligases and RNA polymerases designed to improve efficiency and reduce byproducts in NGS library prep and mRNA synthesis workflows.
Services
Enzyme panels, screening kits, and custom R&D programs to discover and optimize enzymes for pharmaceutical and life-science applications.
Scalable enzymatic manufacturing pathways for siRNA, including two-step enzyme-catalyzed workflows and hybrid ligation approaches to produce high-purity RNA therapeutics.
Screening and optimization of RNA ligases to enable fragment ligation workflows and hybrid approaches for oligonucleotide assembly.
End-to-end directed evolution workflows including library design, recombination, high-throughput screening, sequencing, and iterative optimization to generate application-ready enzyme variants.
Enzyme panels, screening kits, and custom R&D programs to discover and optimize enzymes for pharmaceutical and life-science applications.
Scalable enzymatic manufacturing pathways for siRNA, including two-step enzyme-catalyzed workflows and hybrid ligation approaches to produce high-purity RNA therapeutics.
Screening and optimization of RNA ligases to enable fragment ligation workflows and hybrid approaches for oligonucleotide assembly.
End-to-end directed evolution workflows including library design, recombination, high-throughput screening, sequencing, and iterative optimization to generate application-ready enzyme variants.
Expertise Areas
- Directed evolution and enzyme engineering
- Enzymatic oligonucleotide synthesis (siRNA manufacturing)
- Biocatalysis for small-molecule API synthesis
- Machine-learning-guided protein design
Key Technologies
- Directed evolution
- Enzyme engineering
- Enzymatic oligonucleotide synthesis
- RNA ligation and ligase optimization
News & Updates
A scientific publication discussing enzymes for small molecule API.
Information about MCYP® enzyme products.
A publication on enzyme evolution for cascades.
A scientific publication discussing enzymes for small molecule API.
Information about MCYP® enzyme products.
A publication on enzyme evolution for cascades.