Alpha Preclinical
Alpha Preclinical is a US-owned discovery preclinical research service company founded in 2020. It aims to address the rapid growth demand of the discovery preclinical research sector by providing well-executed, cost-effective, and timely studies to support innovative drug development and research programs. The company values trust, innovation, transparency, and customer-centricity, and collaborates closely with clients to design and execute research programs. Its team comprises highly experienced scientists and technical staff dedicated to advancing preclinical research and supporting the development of emerging therapies.
Industries
Nr. of Employees
small (1-50)
Alpha Preclinical
North Grafton, Massachusetts, United States, North America
Services
End-to-end discovery-stage in vivo services including PK/PD, lead optimization, feasibility, proof-of-concept and efficacy studies with study design, execution and reporting.
Noninvasive whole-animal bioluminescence and fluorescence imaging with 2D/3D tomography and terminal ex vivo tissue imaging to monitor disease progression, cell trafficking and gene expression longitudinally.
Custom rodent colony management including breeding, housing solutions, husbandry optimization and project-level data collection and management.
Aseptic surgical procedures and specialized routes of administration (e.g., intracerebroventricular, intrathecal, intra-articular, implantable pumps) performed in a compliant surgical suite under veterinary oversight.
In vitro assay development and execution including cytokine and molecular ELISAs, flow cytometry assays, CBC differentials, serum chemistry, magnetic bead sorting, and histology/immunohistochemistry.
End-to-end discovery-stage in vivo services including PK/PD, lead optimization, feasibility, proof-of-concept and efficacy studies with study design, execution and reporting.
Noninvasive whole-animal bioluminescence and fluorescence imaging with 2D/3D tomography and terminal ex vivo tissue imaging to monitor disease progression, cell trafficking and gene expression longitudinally.
Custom rodent colony management including breeding, housing solutions, husbandry optimization and project-level data collection and management.
Aseptic surgical procedures and specialized routes of administration (e.g., intracerebroventricular, intrathecal, intra-articular, implantable pumps) performed in a compliant surgical suite under veterinary oversight.
In vitro assay development and execution including cytokine and molecular ELISAs, flow cytometry assays, CBC differentials, serum chemistry, magnetic bead sorting, and histology/immunohistochemistry.
Expertise Areas
- Preclinical in vivo pharmacology
- Pharmacokinetics and pharmacodynamics (PK/PD)
- Gene therapy delivery and evaluation
- Tumor and oncology models
Key Technologies
- In vivo optical imaging (bioluminescence and fluorescence)
- 2D and 3D optical tomography
- Multicolor flow cytometry
- Magnetic bead cell sorting
News & Updates
A study on preventing Type 1 Diabetes in rats using an allele-specific antibody targeting T-cell receptors.
Research on creating standardized insulin protocols for rodent models of Type 1 Diabetes.
Study on the development of autoimmune diabetes in LEW.1WR1 rats.
Introduction of a new mouse model for studying metabolic syndrome.
Research on new peptides that modulate G-protein-coupled kinase with antidiabetic effects.
Study on the BBZDR/Wor rat as a model for type 2 diabetes complications.
A study on preventing Type 1 Diabetes in rats using an allele-specific antibody targeting T-cell receptors.
Research on creating standardized insulin protocols for rodent models of Type 1 Diabetes.
Study on the development of autoimmune diabetes in LEW.1WR1 rats.
Introduction of a new mouse model for studying metabolic syndrome.
Research on new peptides that modulate G-protein-coupled kinase with antidiabetic effects.
Study on the BBZDR/Wor rat as a model for type 2 diabetes complications.