Skin

Skin capabilities address acute trauma, burns, chronic wounds, and infection control by combining advanced dressings, biologics, diagnostics, and reconstruction approaches. Focus areas include rapid hemostasis, infection prevention (including biofilms and AMR), accelerated re-epithelialization, and durable barrier restoration for forward and prolonged care.

Technical Challenges

  • High infection risk in contaminated battlefield wounds, including biofilm formation and antimicrobial resistance (AMR).

  • Severe burns and polytrauma requiring rapid coverage, fluid management, and reconstruction in austere settings.

  • Limited regenerative capacity after large tissue loss—need for scalable dermal substitutes and vascularized constructs.

  • Delayed evacuation and prolonged field care that complicate wound monitoring, dressing changes, and definitive closure.

Emerging Opportunities

  • Point-of-injury antimicrobial strategies that are effective against biofilms and MDR organisms without systemic toxicity.

  • Portable diagnostics and biomarkers for real-time wound status (infection, perfusion, healing trajectory) at point of care.

  • Off-the-shelf, shelf-stable regenerative products that enable durable coverage and reduce need for immediate surgical reconstruction.

  • Decision-support tools and telemedicine-integrated wound management workflows for non-specialists in far-forward environments.

Current and Emerging Technologies in Skin

Advanced antimicrobial dressings and topical therapeutics

Next-generation dressings incorporate antimicrobial peptides, silver nanoparticles, antiseptic-releasing matrices, and quorum-sensing inhibitors to reduce bioburden and disrupt biofilms in contaminated wounds.

Biologic and cell-based regenerative therapies

Engineered skin substitutes, acellular matrices, stem-cell therapies, and growth-factor delivery systems promote angiogenesis and re-epithelialization for volumetric tissue loss and complex wounds.

Point-of-care diagnostics and imaging

Portable fluorescence imaging, biosensors for inflammatory biomarkers, and rapid molecular assays enable early detection of infection and objective wound-healing metrics in austere settings.

Biomaterials and smart dressings

Responsive hydrogels, oxygenating matrices, and electrically active scaffolds adapt to wound microenvironments to control moisture, deliver therapeutics, and stimulate tissue repair.

Telemedicine and decision-support integration

Wearable sensors, secure imaging transfer, and AI-enabled triage tools support remote wound assessment, longitudinal tracking, and guidance for non-specialist providers in prolonged-field-care scenarios.

Importance to Military Medicine

Combat casualty care

Rapid hemorrhage control, contamination management, and durable wound closure reduce morbidity and mortality from blast and penetrating injuries.

Prolonged and austere care

Shelf-stable, easy-to-use skin therapies and remote diagnostics preserve function when evacuation is delayed and resources are limited.

Force readiness and infection control

Preventing wound-associated infections and AMR preserves troop health, reduces downtime, and maintains operational capability.

Reconstruction and long-term recovery

Advanced reconstruction restores form and function after catastrophic injuries, improving rehabilitation and return-to-duty or civilian reintegration.

Alignment with the MTEC Mission

Accelerates transition of battlefield-relevant skin technologies from research to fielded solutions, matching MTEC's DoD-focused mission.

Supports cross-disciplinary projects (trauma, infectious disease, regenerative medicine) that reflect MTEC’s broad portfolio and coalition model.

Prioritizes scalable, shelf-stable, and deployable solutions for the operational environment—a core DoD requirement MTEC advances through consortia and rapid funding pathways.

Dual-Use (Military + Civilian) Applications

Military: rapid field dressings, point-of-injury antimicrobials, and telemedicine-enabled wound triage for prolonged care.

Civilian: advanced burn and trauma centers, chronic wound management (diabetic ulcers, vascular wounds), and scalable disaster-response kits.

Public health: technologies that limit AMR spread, improve outbreak response, and inform infection-prevention protocols across healthcare settings.

Commercial: wearable wound sensors, consumer wound-care products, and reconstructive biologics with civilian market adoption potential.

Explore MTEC Members with Skin Capabilities

MTEC members bring multidisciplinary expertise—biomaterials, microbiology, trauma surgery, imaging, and regulatory pathways—enabling integrated development from bench to battlefield.

Consortium collaboration accelerates access to DoD testbeds, clinical partners, and rapid contracting mechanisms essential for prototype validation and field evaluations.

Industry and academic members scale manufacturing, navigate regulatory approval, and translate dual-use innovations for both military readiness and civilian healthcare benefit.

Explore member profiles to identify collaborators with capabilities in advanced dressings, biologics, diagnostics, and telemedicine-ready solutions for skin and wound challenges.

87 Members with Skin capabilities.

Member
Advanced Regenerative Manufacturing Institute (ARMI)

The Advanced Regenerative Manufacturing Institute (ARMI) is a member-based, nonprofit organization dedicated to advancing the bioeconomy of the United States. Its mission encompasses enhancing manufacturing, healthcare, and education and workforce development, aiming to create a scalable and effective manufacturing ecosystem for engineered cells, tissues, and organs.

Member
Georgia Southern University

Georgia Southern University is a vibrant institution with over 26,100 students across three campuses in Statesboro, Savannah, and Hinesville. The university offers 132 degree programs at the associate, bachelor’s, master’s, and doctorate levels, emphasizing student success, community impact, and research excellence. With a commitment to inclusivity and engagement, Georgia Southern fosters a supportive environment for diverse learners, including military-affiliated and adult students. The university is dedicated to transforming lives through education and community engagement, aligning its programs with regional needs. Additionally, Georgia Southern provides accelerated pathways for students to fast-track their master's degrees, enhancing educational opportunities. The university also emphasizes career readiness and public impact research, preparing students for successful careers and contributing to community development.

Member
FiteBac Pharma

FiteBac Technology/FiteBac Pharma's K21 uniquely targets the underlying disease state, given that most diseases involve microbial-associated inflammation and mitochondrial dysfunction. FiteBac Technology innovations stem from the work of numerous international academic research scientists. FiteBac Pharma K21 is the blockbuster antimicrobial small molecule designed to modulate biological, immunological, and metabolic systems for treating a wide range of infectious and inflammatory diseases. This patented drug substance has demonstrated the ability to safely eliminate bacterial, fungal, and viral infections, enhance innate immunity, induce mitophagy while improving mitochondrial and cellular metabolism, accelerate wound healing, and even promote the development of zebrafish and chickens, leading to increased adult mass. Rigorous research from Dr. Bhupesh Prusty's laboratory and Dr Christopher Rongo's laboratory is focused on various aspects of mitochondrial remodeling and reprograming, as well as mitochondrial-to-nuclear signaling with K21.

Member
Auburn University

Auburn University Research & Economic Development is dedicated to advancing research and economic growth through a collaborative effort among its various colleges and departments. The organization focuses on fostering innovation, supporting faculty and student research, and facilitating partnerships with industry and government to address societal challenges and enhance the quality of life. Recent initiatives include the launch of the Team Science Series to promote interdisciplinary collaboration and the development of the Gulf Coast Engineering Research Station to address coastal environmental challenges.

Member
SanaHeal

SanaHeal is dedicated to developing next-generation bioadhesive technologies inspired by nature to solve significant challenges in healthcare. Their innovative solutions are designed to adhere to wet and uneven surfaces, providing rapid and robust adhesion for various medical applications.

Member
SERDA Therapeutics

SERDA Therapeutics is a clinical stage biopharmaceutical company focused on developing innovative solutions for wound care, particularly in the treatment of burn injuries and chronic ulcers. The company aims to provide fast and effective therapeutic debridement through its proprietary enzymatic product, SN514, which is designed to enhance healing by selectively removing necrotic tissue.

Member
University of Arkansas

The Institute for Integrative & Innovative Research (I3R) at the University of Arkansas is dedicated to pioneering solutions to complex societal challenges through convergence research. With a mission to advance research excellence and stimulate economic development, I3R focuses on deploying innovations at scale through collaboration across various sectors, including academia, industry, and government.

Member
Spartan Medical

Spartan Medical is a medical solutions company serving VA medical centers, Department of Defense (DoD) facilities, civilian hospitals, and ambulatory surgery centers across the United States and internationally. The company specializes in advanced medical devices, surgical solutions, and support services, with a history of adapting to emergent healthcare challenges and logistical demands. Spartan Medical has provided solutions in public health crises, such as COVID-19 mitigation, and delivers comprehensive procurement, logistical, and operational support for healthcare organizations. It operates as a certified Service-Disabled Veteran-Owned Small Business (SDVOSB) and is recognized for its significant presence in federal healthcare contracting.

Member
The University of Chicago

The University of Chicago is a prestigious urban research university committed to rigorous inquiry and intellectual freedom. Founded in 1890, it has produced numerous Nobel laureates and is known for its transformative education and groundbreaking research across various fields. The university fosters an inclusive and diverse learning environment, encouraging participation from all community members.

Member
Boston University

Boston University is a major research institution committed to leading breakthroughs across various disciplines. The Office of Research supports and advances research excellence, fostering collaboration among researchers, industry partners, and government leaders to address significant societal challenges.

Member
Baylor University

Baylor University is a preeminent Christian research university committed to addressing the world's most meaningful challenges through top-tier research and scholarship. Recognized as an R1 research institution, Baylor focuses on infusing its distinct Christian mission into its research initiatives, fostering a commitment to excellence and innovation.

Member
Entropia Labs

Entropia Labs focuses on advancing functional medicine and wellness therapeutics through AI-driven molecular design and delivery technologies. The company aims to close the gap between promising treatments and rigorous scientific validation, with an emphasis on health-span extension.

Member
Kane Biotech

Kane Biotech is a Canadian-based biotechnology company focused on the research, development, and commercialization of products that prevent and remove microbial biofilms. Established in 2001, the company aims to improve human and animal welfare through innovative solutions to biofilm-related challenges and antimicrobial resistance. With a strong portfolio of 54 patents and patents pending, Kane Biotech is recognized as a leader in biofilm research and technology, and is listed on the TSX Venture Exchange under the symbol 'KNE' and on the OTC Markets under the symbol 'KNBIF'.

Member
NuShores Biosciences LLC

NuShores Biosciences LLC, founded in 2014, is dedicated to commercializing patented bone and tissue regeneration technologies developed at the University of Arkansas at Little Rock. The company aims to improve the quality of life for individuals with severe tissue regeneration needs through innovative solutions like the NuCress™ bone scaffold technology, which is designed to promote healing in large segmental bone defects.

Member
Exponent

Exponent is a multidisciplinary science and engineering consulting firm serving sectors including healthcare, energy, manufacturing, and consumer products. From medical devices, pharmaceuticals, and supplements to digital health and wearables, we deliver rigorous science that quantifies impacts on human health. Exponent helps you push the envelope on the development, deployment, safety, and effectiveness of cutting-edge drugs, devices, and diagnostics — concomitantly balancing benefits and risks. Count on our multidisciplinary, data-driven, evidence-based assessments to give you clarity on your most complex product needs and challenges. With lives on the line, innovations that support healthcare demand the highest levels of scientific rigor. Whether you’re developing a novel drug, a sturdier stent, or a faster flu test, you need clear answers to complex questions, quickly. Exponent supports our life sciences clients across the total product lifecycle by solving critical design, regulatory, safety, and market access challenges. We can collaborate with you throughout your journey, helping you navigate risks and opportunities — and optimize outcomes — with science-based strategies and specialized expertise.

Member
Solventum

Solventum is a healthcare company dedicated to enabling better, smarter, and safer healthcare solutions. With a legacy of innovation, Solventum focuses on improving patient outcomes through advanced medical technologies, oral care solutions, health information technology, and purification and filtration systems.

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Projects

Technology Showcase

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University of California San Francisco

TemPredict: AI-Driven Wearable Monitoring for Early Illness Detection and Warfighter Readiness

TemPredict: AI wearables detect early illness and health risks to support warfighter readiness.

Arizona State University

ASU Crosscutting Technologies to Enhance Military Medical Readiness and Resilience

Dr. Rachel Cassalia leads MTEC-supported efforts at ASU to shift military health from reactive care to proactive readiness through data-driven prevention.

University of Pittsburgh

Topical Metformin Lotion for Tendinopathy Prevention

University of Pittsburgh study shows topical metformin prevents overuse tendon injury. This work was sponsored through MTEC project 22-02-MPAI-014.

Theradaptive

Theradaptive’s RESTORE Trial Initiation for OsteoAdapt™ DE

Theradaptive launches RESTORE Phase I/II trial of OsteoAdapt™ DE for faster, precision bone healing in craniofacial injuries. MTEC-funded study targets improved recovery for military and civilian patients.

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