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Publication Number
US-9999639-B2
Publication Date
2018-06-19
Expiration Date
Abstract
The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.
Core Innovation
The patent describes compositions suitable for topical administration made from fish eggs. The method includes providing fish eggs, processing the eggs to provide a cytoplasmic fraction, heating the cytoplasmic fraction to form a heated cytoplasmic fraction, and combining the heated cytoplasmic fraction with one or more pharmaceutically acceptable carriers.
The composition is selected from topical dosage forms including a cream, gel, emulsion, ointment, spray, powder, and a lotion. The compositions are applicable to wound healing and to scarring, including keloids, hypertrophic scars, and widened scars, and are described for skin health and appearance.
The patent further discusses gene, protein, and cell analyses, including imaging and gene-expression targeting, and describes outcomes including wound healing, scar management, accelerated wound healing, collagen production, collagen deposition, epithelialization, angiogenesis, and granulation tissue formation.
Claims Coverage
The claim coverage identifies one independent claim and dependent refinements. The main inventive features center on generating a heated cytoplasmic fraction from fish eggs and formulating it with pharmaceutically acceptable carriers into specified topical dosage forms.
Fish egg cytoplasmic fraction for topical composition
A method of making a composition suitable for topical administration from fish eggs by providing fish eggs and processing the eggs to provide a cytoplasmic fraction from the eggs.
Heating the cytoplasmic fraction for a heated cytoplasmic fraction
Heating the cytoplasmic fraction to a temperature of from about 50°C to about 90°C for a period of greater than one minute to provide a heated cytoplasmic fraction.
Formulating with pharmaceutically acceptable carriers into selected topical dosage forms
Combining the heated cytoplasmic fraction with one or more pharmaceutically acceptable carriers to provide a composition suitable for topical administration selected from the group consisting of a cream, gel, emulsion, ointment, spray, powder and a lotion.
Selecting fertilized and/or unfertilized fish eggs
Further selecting eggs from fertilized and/or unfertilized eggs.
Homogenizing and centrifuging to separate lipids and solids
Further processing the eggs by homogenizing them and then centrifuging to separate lipids and solids from the cytoplasmic fraction.
Overall, the claims center on making a heated cytoplasmic fraction from fish eggs and formulating it with pharmaceutically acceptable carriers into a specified set of topical dosage forms, with dependent refinements specifying fertilized/unfertilized egg selection and a homogenization-centrifugation sequence to separate lipids and solids.
Stated Advantages
Improves or restores skin health and appearance.
Supports wound healing.
Supports scar management.
Documented Applications
Topical administration to skin for wound healing.
Topical administration to skin for scar healing/scar management.
Use for improving or restoring skin health and appearance.
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