Subcutaneous injection product for cattle for inducing superovulation
Inventors
Kimura, Koji • Matsuyama, Shuichi • Ishii, Kenyo • Seki, Makoto • Hamada, Toshiya
Assignees
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Publication Number
US-9987359-B2
Publication Date
2018-06-05
Expiration Date
Abstract
The present invention provides a subcutaneous injection product for cattle for inducing superovulation characterized by comprising aluminum hydroxide gel and an efficient amount of a gonadotropin, wherein the concentration of the aluminum hydroxide is, in terms of the amount of aluminum, higher than or equal to 0.2 mg/mL and lower than 1.0 mg/mL, which is a subcutaneous injection product that is useful for producing good calves and that can induce superovulation in a cow by a single administration. The present invention also provides a method for producing good calves undergoing steps of subcutaneously injecting the aforementioned injection product into a cow to thereby induce superovulation, inducing estrus in the cow, conducting artificial insemination, and then collecting fertilized eggs.
Core Innovation
The disclosure describes a subcutaneous injection product for cattle for inducing superovulation by single administration. The product comprises aluminum hydroxide gel and a gonadotropin, and the aluminum hydroxide is defined as an aluminum hydroxide concentration, in terms of aluminum, within the range of 0.2 to less than 1.0 mg/mL.
The claim-limited range is described as 0.3 to 0.6 mg/mL, and the disclosure associates the aluminum hydroxide concentration and the gonadotropin amount with inducing adequate superovulation. The product is configured to include an aluminum hydroxide gel container and a gonadotropin container, and optionally a liquid for dissolving the gonadotropin.
A related use for producing good calves is described, including subcutaneous injection for inducing estrus, artificial insemination, and collection of fertilized eggs (embryos). The disclosure also describes minimizing swelling and induration at the injection site and reducing cattle stress and veterinary workload, while maintaining sufficient transplantable embryos.
Claims Coverage
The independent claim family coverage centers on a subcutaneous injection product for cattle that induces superovulation by single administration using aluminum hydroxide gel and a gonadotropin, with the aluminum hydroxide concentration, in terms of aluminum, constrained to 0.3 to 0.6 mg/mL. Four inventive features are identified across the independent and dependent claims.
Subcutaneous injection product for inducing superovulation with aluminum hydroxide concentration defined in mg/mL
A subcutaneous injection product for cattle for inducing superovulation, comprising aluminum hydroxide gel and gonadotropin present in an amount effective to induce adequate superovulation, wherein the concentration of the aluminum hydroxide is, in terms of the amount of aluminum, 0.3 to 0.6 mg/mL.
Subcutaneous injection product with aluminum hydroxide total amount per administration
The subcutaneous injection product for cattle for inducing superovulation, wherein the total aluminum hydroxide content, in terms of aluminum, is 1.5 to 3.0 mg per administration.
Subcutaneous injection product with gonadotropin content defined in Armour Units per administration
The subcutaneous injection product for cattle for inducing superovulation, wherein the gonadotropin content is 10 to 50 Armour Units, or an equivalent biological valence, per administration.
Kit for preparing injection product with separate containers for aluminum hydroxide gel, gonadotropin, and dissolving liquid
A kit including a container with an aluminum hydroxide gel at a defined concentration, a container with gonadotropin at a defined biological amount per administration, and a container with liquid for dissolving the gonadotropin.
Method for obtaining fertilized eggs using subcutaneous injection with estrus induction and artificial insemination
A method for obtaining fertilized eggs by subcutaneously injecting cattle with the injection product, inducing estrus and performing artificial insemination, and then collecting the fertilized eggs.
Overall claim coverage focuses on a defined-aluminum subcutaneous injection product combining aluminum hydroxide gel and a gonadotropin to induce adequate superovulation, with additional constraints on aluminum total amount and gonadotropin amount, plus kit containerization and a method for obtaining fertilized eggs using estrus induction and artificial insemination.
Stated Advantages
Inducing adequate superovulation while minimizing swelling and induration.
Reducing cattle stress and veterinary workload.
Documented Applications
Producing good calves by subcutaneous injection to induce estrus, followed by artificial insemination and collection of fertilized eggs (embryos).
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