Durable antimicrobial treatments for textiles and other substrates
Inventors
Toreki, William • Kanga, Rustom S.
Assignees
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Publication Number
US-9986742-B2
Publication Date
2018-06-05
Expiration Date
Abstract
This invention relates to regenerable antimicrobial coatings with long-lasting efficacy for use in medical applications including implants, medical instruments or devices, and hospital equipment. The same coatings would also have broad utility in the consumer, industrial, and institutional markets. The coating technology would be based on sequestration of hydrogen peroxide (HP) by zinc oxide binders incorporated into the coatings.
Core Innovation
The invention provides regenerable durable antimicrobial activity by using a water-borne system in which hydrogen peroxide is sequestered by a polymer doped with a metal derivative. The metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from zinc, magnesium, titanium, and zirconium, and the polymer has a defined water absorbency. Antimicrobial activity is configured to be regenerated when exposed to aqueous hydrogen peroxide.
In one aspect, the invention specifies a liquid water-borne formulation as an aqueous dispersion, suspension, emulsion, or solution that includes the metal derivative, the polymer, and hydrogen peroxide within defined concentration ranges. The polymer water absorbency is between 0.5% and 20% (w/w), the metal derivative is 0.1% to 15% (w/w), and the hydrogen peroxide concentration is 0.1% to 10% (w/w). The coating formulation is applied to a substrate and then dried to impart durable antimicrobial activity to the substrate.
In another aspect, the invention provides a regenerable antimicrobial water-borne coating on a substrate comprising a doped polymer containing sequestered hydrogen peroxide, where subsequent exposure to aqueous hydrogen peroxide regenerates the antimicrobial activity. The coating is evaluated by ASTM Standard Method E2180 at least 24 hours after preparation, and provides at least a 3-log reduction of viable Escherichia coli bacteria greater than that of a corresponding coating that has not been exposed to hydrogen peroxide.
Claims Coverage
The independent claims are clm-00001, clm-00009, and clm-00016, covering a liquid water-borne formulation, a method of enhancing and regenerating durable antimicrobial activity on a substrate surface, and a regenerable antimicrobial water-borne coating with sequestered hydrogen peroxide. Across the independent claims, the inventive structure uses a metal derivative with defined identities and concentration ranges, a polymer with a defined water absorbency, and hydrogen peroxide configured for sequestration and regeneration.
Liquid water-borne antimicrobial formulation with metal derivative, polymer, and hydrogen peroxide
A liquid water-borne formulation for imparting durable antimicrobial activity to a substrate as an aqueous dispersion, suspension, emulsion, or solution comprising a metal derivative that is a hydroxide, oxide, or peroxide of zinc, magnesium, titanium, or zirconium; a polymer having water absorbency between 0.5% and 20% (w/w); and hydrogen peroxide having a concentration between 0.1% and 10% (w/w).
Regenerating durable antimicrobial activity by applying and drying a water-borne coating formulation
A method of enhancing and regenerating durable antimicrobial activity of the surface of a substrate by providing on the surface a water-borne coating formulation for imparting durable antimicrobial activity, followed by drying the substrate.
Regenerable antimicrobial water-borne coating with doped polymer sequestering hydrogen peroxide
A regenerable antimicrobial water-borne coating on a substrate comprising a metal derivative that is a hydroxide, oxide, or peroxide of zinc, magnesium, titanium, or zirconium; a polymer doped with the metal derivative and having water absorbency between 0.5% and 20% (w/w); and sequestered hydrogen peroxide, where the doped polymer is determined capable of sequestering hydrogen peroxide when exposed to a source of aqueous hydrogen peroxide and where antimicrobial activity is regenerated on subsequent exposure to aqueous hydrogen peroxide.
Collectively, the independent claims cover aqueous and water-borne antimicrobial compositions and coatings in which a metal-derivative-doped polymer with defined water absorbency sequesters hydrogen peroxide, and antimicrobial activity is regenerable upon subsequent exposure to aqueous hydrogen peroxide.
Stated Advantages
Provides regenerable antimicrobial activity upon subsequent exposure to aqueous hydrogen peroxide.
At least a 3-log reduction of viable Escherichia coli bacteria greater than a corresponding coating not exposed to hydrogen peroxide when tested using ASTM Standard Method E2180 at least 24 hours after preparation.
Imparts durable antimicrobial activity to a substrate using a water-borne coating formulation followed by drying.
Documented Applications
Imparting durable antimicrobial activity to substrates including medical and healthcare frequent touch surfaces.
Textile applications where antimicrobial durability and regeneration are maintained through laundering cycles.
Use on textile articles made from cotton, rayon, polyester, nylon, acrylic, or mixtures thereof, including absorbent/protective garments and coverings such as diapers, surgical gowns, isolation gowns, lab coats, gloves, surgical scrubs, head cover, hair cover, face mask, floor mat, lamp handle cover, exam table cover, cast liner, splint liner, padding, mattress cover, bedding, sheet, towel, clothing, underwear, sock, shoe-cover, protective garment for military or other use, apparel for food handling, and carpet.
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