Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide
Inventors
Tolmie, Craig R. • Milsap, Jeff • Acker, Jaron M.
Assignees
Mallinckrodt Pharma IP Trading DAC • Therakos Inc • INO Therapeutics LLC • Mallinckrodt Critical Care Finance Inc
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Publication Number
US-9981097-B2
Publication Date
2018-05-29
Expiration Date
Abstract
Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (NO) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. The long term sensitivity drift of catalytic type electrochemical gas sensors may be addressed using calibration schedules, which can factor in the absolute change in set dose of NO being delivered to the patient that can drive one or more baseline calibrations. The calibration schedules can be used to reduce the amount of times the sensor goes offline.
Core Innovation
The described subject matter relates to systems and methods for therapeutic nitric oxide (NO) delivery using catalytic electrochemical NO sensors. It addresses long-term sensitivity drift during prolonged operation, including sensitivity drift associated with atypical continuous and/or high-concentration exposure that can impact therapeutic delivery based on sensor readings.
To manage the drift, the system uses calibration and recalibration approaches that account for absolute set-dose changes by sensor recalibration schedules. It includes reducing sensor offline time by calibrating in a manner tied to set dose change detection and planned recalibration behavior.
Updated calibration lines are generated using new baseline calibration value readings and stored prior calibration slopes. The calibration activity can be postponed when predefined conditions are present, including alarm conditions, user interaction, interfering gas detection, and sensor output out-of-range/threshold-range events occurring within predefined time windows.
Claims Coverage
Not explicitly described in patent.
Not explicitly described in patent.
Stated Advantages
Reduces long-term sensitivity drift impact on therapeutic NO delivery when using catalytic electrochemical NO sensors.
Reduces sensor offline time by calibrating in relation to sensor recalibration schedules and set dose change detection.
Generates updated calibration lines using new baseline readings and stored prior calibration slopes.
Avoids or postpones calibration during alarm conditions, user interaction, interfering gas detection, or sensor output out-of-range/threshold-range events within predefined time windows.
Documented Applications
Therapeutic nitric oxide delivery using catalytic electrochemical NO sensors in a patient breathing circuit with gas sampling and valves/controller architecture.
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