Intravascular optical imaging system
Inventors
Wang, Tianshi • Lancee, Charles Theodoor • Van Der Steen, Antonius Franciscus Wilhelmus • Van Soest, Gijs
Assignees
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Abstract
A catheter-based optical imaging system for imaging a patient includes a catheter-based imaging device configured to direct optical radiation towards a vessel wall and to receive reflected radiation therefrom. A displacement mechanism is configured to vary the position of the imaging device relative to the catheter as a function of time during an imaging scan. An input is configured to receive cardiac event timing data, such as ECG data, from the patient. A trigger module is configured to initiate an imaging scan based on the cardiac event timing obtained from the cardiac event timing data. By triggering the optical imaging scans between cardiac events, artifacts in the image data can be reduced or eliminated.
Core Innovation
A catheter-based optical imaging system directs optical radiation towards a vessel wall and receives reflected radiation therefrom using a catheter-based imaging device. During an imaging scan, a displacement mechanism varies the position of the imaging device relative to the catheter as a function of time, and cardiac event timing data is received and used by a trigger module to initiate an imaging scan based on the cardiac event timing data.
The imaging device includes an optical element rotatable about the catheter longitudinal axis to generate frames of image data, where each frame corresponds to at least part of a circumferential scan. A longitudinal displacement mechanism drives the optical element along a longitudinal axis of the catheter so successive frames correspond to different longitudinal positions, and the trigger module initiates longitudinal displacement of the optical element by reference to a detected cardiac event.
The system completes a 3D imaging scan comprising the successive frames of the image data within one cardiac cycle defined between two cardiac events identified within the cardiac event timing data. Circumferential frame generation by rotation and longitudinal frame sequencing by displacement are synchronized to the patient cardiac event timing data so the 3D imaging scan is performed within a cardiac-cycle window.
Claims Coverage
The disclosed claim set includes three independent claims: a system in a patient vessel, a method of optical imaging in a vessel, and a catheter-based optical imaging system with an axial-to-radial optical pathway. Across the independent claims, inventive features focus on catheter-based optical imaging directed to a vessel wall and reflected radiation detection, timing and initiation using cardiac event timing data with completion of a 3D imaging scan within one cardiac cycle between two identified cardiac events, and optical element generation of circumferential frames synchronized with longitudinal displacement to produce successive frames at different longitudinal positions; a further independent claim emphasizes the axial optical pathway and distal optical element that directs radiation into a radial optical path and varies that radial direction via rotation, including specified transmissive and reflective interfaces.
Cardiac-event triggered catheter-based optical imaging scan synchronized to one cardiac cycle
A catheter-based optical imaging system comprising an input configured to receive cardiac event timing data from the patient and a trigger module configured to initiate an imaging scan based on the cardiac event timing data, wherein the trigger module initiates longitudinal displacement of the optical element by the displacement mechanism by reference to a detected cardiac event, and is configured to complete a 3D imaging scan comprising successive frames within one cardiac cycle defined between two cardiac events identified within the cardiac event timing data.
Rotatable optical element generating circumferential frames synchronized with longitudinal displacement
An optical element rotatable about the catheter longitudinal axis to generate frames of image data, each frame corresponding to at least part of a circumferential scan, wherein the displacement mechanism comprises a longitudinal displacement mechanism configured to drive the optical element along a longitudinal axis of the catheter such that successive frames of image data correspond to different longitudinal positions.
Method of optical imaging using cardiac-event timing to complete a 3D imaging scan within one cardiac cycle
A method of optical imaging within a vessel of a patient comprising obtaining cardiac event timing data from the patient, initiating an imaging scan based on the cardiac event timing, rotating an optical element about the catheter longitudinal axis to generate frames corresponding to at least part of a circumferential scan, using a longitudinal displacement mechanism to vary the position of the imaging device relative to the catheter as a function of time during the imaging scan so successive frames correspond to different longitudinal positions, initiating longitudinal displacement by reference to a detected cardiac event, and completing a 3D imaging scan comprising the successive frames within one cardiac cycle defined between two cardiac events identified within the cardiac event timing data.
Axial optical pathway and distal rotatable optical element directing radiation into a radial optical path with transmissive and reflective interfaces
A catheter-based optical imaging system comprising an optical pathway extending along a catheter in an axial direction from a proximal end to a distal end; an optical element disposed at the distal end of the catheter configured to direct optical radiation from the axial optical path to a radial optical path extending radially from the catheter longitudinal axis towards a vessel wall and to receive reflected radiation therefrom; wherein the optical element is rotatable about the catheter longitudinal axis so as to vary the direction of the radial optical path; and wherein the optical element comprises a first transmissive interface, a second transmissive interface and a first reflective interface.
Across the independent claims, the core claim coverage centers on synchronizing a catheter-based 3D optical imaging scan using a rotatable optical element for circumferential frame generation and a longitudinal displacement mechanism for successive longitudinal frame positions, with a trigger module that initiates and completes the scan within a single cardiac cycle between two identified cardiac events from patient cardiac event timing data. A separate independent claim further anchors a catheter optical architecture with an axial-to-radial optical pathway and a distal rotatable optical element having first and second transmissive interfaces and a first reflective interface.
Stated Advantages
Reduces motion artefact.
Improves longitudinal sampling/image quality at higher rotational and laser sweep rates.
Reduces flush medium reduction (flush volume)
Documented Applications
Intravascular optical coherence tomography imaging within a vessel, including an intracoronary context, using catheter-based optical imaging synchronized to patient cardiac event timing data.
Performing 3D imaging scan acquisition comprising successive frames within one cardiac cycle defined between two cardiac events identified within cardiac event timing data.
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