Oxazoline polymer compositions and use thereof
Inventors
Yin, Ray • Pan, Jing • Qin, Dujie • Zhang, Yubei
Assignees
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Publication Number
US-9944755-B2
Publication Date
2018-04-17
Expiration Date
Abstract
Compositions comprising an oxazoline polymer and optional linkers to carry a variety of molecules.
Core Innovation
The invention provides functionalized polyoxazoline (POX) polymer compositions. The compositions comprise a first and a second functionalized POX polymer joined by a difunctional initiator comprising a cleavable disulfide bond.
Each of the first and second functionalized POX polymers includes a water soluble POX polymer reacted with a first linker, L, followed by reaction with a second linker, M, such that M is reacted with a bioactive material, B. The first linker, L, is ammonia or is based on an amine group or an imino group, and the second linker, M, connects the functionalized POX to the bioactive material, B.
The disclosed compositions are further described for use with bioactive materials including binding-pair members, binding assay materials, pharmaceutically active agents, polypeptides, polynucleotides, small molecule drugs, and antibody or antigen-binding portions. The disclosure also describes POX-based conjugate and array-style uses, including protein microarrays and protein immobilization.
Claims Coverage
The independent claim identifies one inventive architecture with three structural linkages: two functionalized POX polymers joined by a cleavable disulfide-containing initiator, each POX reacted with a first linker L, and L reacted with a second linker M that is reacted with a bioactive material B.
Two functionalized POX polymers joined by a cleavable disulfide initiator
A functionalized polyoxazoline (POX) polymer composition comprising a first and a second functionalized POX polymer, joined by a difunctional initiator comprising a cleavable disulfide bond.
POX reacted with a first linker L of ammonia or an amine/imino group
Each of said first and said second functionalized POX polymer comprises a water soluble POX polymer reacted with a first linker, L, wherein L is ammonia, or said POX polymer is reacted with an amine group or an imino group of L.
POX-linked second linker M reacted with a bioactive material B
L is reacted with a second linker, M; and M is reacted with a bioactive material, B.
The claim coverage centers on the conjugate architecture that joins two functionalized water soluble POX polymers using a difunctional initiator having a cleavable disulfide bond, with each POX functionalized via a first linker L and a second linker M that is reacted with a bioactive material B.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Protein microarrays and protein immobilization.
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