Antithrombogenic hollow fiber membranes and filters
Inventors
Mullick, Sanjoy • Chang, Weilun • Chen, Hanje • STEEDMAN, Mark A. • Esfand, Roseita
Assignees
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Publication Number
US-9884146-B2
Publication Date
2018-02-06
Expiration Date
Abstract
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
Core Innovation
The invention provides an antithrombogenic extracorporeal blood circuit using polymeric base materials for hollow fiber membranes, potted fiber bundles, and blood tubing, where the polymeric base is admixed with a surface modifying macromolecule (SMM). The SMM is present at about 0.005–10 wt% and includes polyfluoroorgano groups (FT) tethered to defined soft/hard segment block structures via coupling/link segments.
The soft segments include polypropylene oxide or polytetramethylene oxide, and the hard segments include hexamethylene diisocyanate or hexamethylene diisocyanate biuret trimer, with the structure families given by formulas (I)–(XIV) and exemplified variants including VII-a and XI-a. The document describes antithrombogenic behavior attributed to surface migration of the SMM to a top surface region and to newly cut/formed interfaces.
The stated goal is to reduce thrombi deposition and maintain performance during use, including reducing operating pressure after hours of use and increasing functional working life. The described performance is quantified as at least 10–95% reduced thrombi deposition, reduced operating pressure after hours of use, increased functional working life, and reduced adverse events, including in settings with reduced/no anticoagulant.
Claims Coverage
The partial content provides one independent claim (clm-00001), directed to a hollow fiber membrane construction. The claim coverage is focused on a specified hollow fiber membrane material system defined by a base polymer, an SMM loading range, and an SMM structural definition through specified formulas.
Hollow fiber membrane with base polymer admixed with SMM
A hollow fiber membrane in which a base polymer is admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule.
Base polymer selected from polysulfone or polyacrylonitrile
The hollow fiber membrane uses a base polymer that is a polysulfone or a polyacrylonitrile.
SMM having a block structure with polyfluoroorgano groups and defined soft/hard segments
The surface modifying macromolecule has a structure according to specified formulas, wherein a soft oligomeric segment is connected with a hard segment and tethered to a polyfluoroorgano group (FT).
Alternative SMM structure with urethane hard segment and defined soft segments
An alternative surface modifying macromolecule structure is defined with a soft segment, a hard segment including a urethane, a polyfluoroorgano group (FT), and an integer n range.
Overall, the independent claim coverage centers on a hollow fiber membrane that combines a polysulfone or polyacrylonitrile base polymer with 0.005–10 wt% of a surface modifying macromolecule having polyfluoroorgano groups tethered to defined soft/hard block segment structures.
Stated Advantages
At least 10–95% reduced thrombi deposition.
Reduced operating pressure after hours of use.
Increased functional working life.
Reduced adverse events, including in settings with reduced/no anticoagulant.
Documented Applications
Antithrombogenic extracorporeal blood circuits using hollow fiber membranes, potted fiber bundles, and blood tubing.
Hemofiltration, hemodialysis, and hemodiafiltration contexts described for extracorporeal blood handling.
Blood-loop hemofilter thrombosis testing using gamma-count and header pressure measurements.
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