Compositions comprising peroxyacid and methods for producing and using the same
Inventors
Neas, Edwin D. • Skinner, John D.
Assignees
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Publication Number
US-9877483-B2
Publication Date
2018-01-30
Expiration Date
Abstract
The present invention provides methods for producing a non α-keto peracid that has lower toxicity and lower corrosivity. The present embodiments also provide methods and compositions for reducing microbes on a surface, methods, and compositions for preventing and reducing infectious vegetative bacteria on a substrate, and methods and compositions for treating a wound. In particular, compositions of the invention provide for a mixture of an α-keto peracid and a non α-keto peracid that works synergistically to reduce microbes on a surface, to prevent vegetative bacteria on a surface and to heal a wound in animals or humans.
Core Innovation
The invention relates to a method for producing non-α-keto peracids by contacting at least one first α-keto carboxylic acid with an oxidizing agent to form a mixture and stirring the mixture at a temperature from −20° C. to 0° C. to produce non-α-keto peracids comprising at least one first percarboxylic acid. The approach uses α-keto carboxylic acids and an oxidizing agent to obtain percarboxylic acids that are not α-keto peracids at the point of use.
In a further aspect, the invention includes contacting pyruvic acid with an oxidizing agent to form a mixture and stirring the mixture at a temperature from −20° C. to 0° C. so as to produce a mixture containing non-α-keto peracids comprising percarboxylic acid(s). The document also describes optional refinements through selection of the oxidizing agent and through quantitative constraints on oxidizing agent to acid relationships and reaction time ranges.
The resulting non-α-keto peracids, including peroxycarboxylic acid forms and percarboxylic acids derived from α-keto carboxylic acids, are described as being used to reduce microbes. The disclosed microbial targets include bacteria, fungi/mycobacteria, spores, and biofilms, including synergistic biocidal effects associated with the combination of α-keto and non-α-keto peracids.
Claims Coverage
The partial content provides two independent method claims, together covering two inventive features: forming non-α-keto peracids from at least one first α-keto carboxylic acid, and forming non-α-keto peracid mixtures specifically from pyruvic acid, both by contacting with an oxidizing agent and stirring at temperatures from −20° C. to 0° C. Dependent claims refine the inventive concept by constraining oxidizing agent selection, quantitative ratios, reaction times, and by defining additional α-keto carboxylic acids and a skin patch.
Formation of non-α-keto peracids from α-keto carboxylic acids under controlled stirring temperatures
Contacting at least one first α-keto carboxylic acid with an oxidizing agent to form a mixture, and stirring the mixture at a temperature from −20° C. to 0° C. to produce non-α-keto peracids comprising at least one first percarboxylic acid.
Formation of non-α-keto peracid mixture from pyruvic acid under controlled stirring temperatures
Contacting pyruvic acid with an oxidizing agent to form a mixture, and stirring the mixture at a temperature from −20° C. to 0° C.
Across the two independent claims, the core coverage is the preparation of non-α-keto peracids, including percarboxylic acid(s), by contacting an α-keto carboxylic acid including pyruvic acid with an oxidizing agent and stirring the mixture in the temperature range of −20° C. to 0° C., with dependent claims further narrowing the method by specifying oxidizing agent selection, ratios, reaction time ranges, additional α-keto carboxylic acids, and integration into a skin patch.
Stated Advantages
Lower toxicity/corrosivity.
Improved wound healing.
Synergy between α-keto and non-α-keto peracids.
Stability requirements for shelf-life (~12 months).
Documented Applications
Treat or prevent wound infections using compositions/methods involving non-α-keto peracids that reduce microbes including bacteria, fungi/mycobacteria, spores, and biofilms.
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