Substrate having an electron donating surface with metal particles comprising palladium on said surface

Inventors

Ohrlander, Mattias • Södervall, Billy

Assignees

Bactigaurd AB • Bactiguard AB

Abstract

The invention concerns a substrate with an electron donating surface with metal particles on the surface. The particles comprise palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum. The amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopedic implants, orthopedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

Core Innovation

The invention provides a device comprising a substrate having an electron donating surface, with metal particles deposited on the electron donating surface. The metal particles comprise palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum.

The disclosed substrate and deposited palladium-containing metal particles are associated with modifications of surface-related properties, including hydrophobicity and protein adsorption. The coated surfaces are also associated with reduced bacterial adhesion and bacterial growth, including growth of E. coli, as well as tissue ingrowth and effects related to complement activation and inflammatory response.

The disclosure further associates the palladium-containing metal particle coatings with effects related to blood clotting (thrombogenicity) and with friction coefficient and surface hardness. Examples in the disclosure include coated biomedical objects such as contact lenses, pacemakers, stents, dental implants, catheters, dialysis equipment, wound dressings, and ECG electrodes.

Claims Coverage

Independent claim clm-00001 defines the core device concept, and the dependent claims refine the substrate options, quantitative deposition/loading, palladium-to-noble-metal composition ratio, and particle physical characteristics such as average size, with additional refinements tied to associated surface functions and a manufacturing example.

Across the claim set, the inventive concept centers on a substrate with an electron donating surface bearing deposited palladium-containing metal particles, further constrained by the deposited amount per area, the palladium-to-non-palladium metal ratio, and the average particle size, with optional refinements to specific substrate materials and a deposition-from-suspension manufacturing example.

Stated Advantages

Documented Applications