Clinical assessment of fragile bone strength
Inventors
Kopperdahl, David L. • Hoffmann, Paul Frederick • Lee, David Choen • Hayeck, Garry Thomas • Keaveny, Tony M.
Assignees
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Publication Number
US-9848818-B1
Publication Date
2017-12-26
Expiration Date
Abstract
A system and method for the use of the results from a structural analysis of a patient's bone from a clinical scan, to be used clinically to manage patients in a widespread and consistent fashion.
Core Innovation
The disclosed invention provides a computer-implemented method and corresponding non-transitory computer readable storage medium to classify subjects and patients for a fragile-bone-strength condition. The method specifies a fragile-bone-strength interventional threshold value of a bone strength parameter for a population data set, where the interventional threshold value provides an indication of a fragile-bone-strength condition.
For each subject in the population data set, the method derives, using a finite element analysis, a bone strength value of the bone strength parameter and receives a bone mineral density (BMD) value. The method pairs the bone strength value and the BMD value to produce a set of paired measurements across the plurality of subjects, and the interventional threshold value is specified based on the statistical correspondence of the paired measurements and an established BMD interventional threshold value for osteoporosis.
The method further enables patient classification by deriving, using finite element analysis, a bone strength value of a bone portion of the patient and comparing that bone strength value to a predetermined interventional threshold value for the fragile-bone-strength condition. Responsive to the processor-implemented comparison, the method generates a fragile-bone-strength classification for the patient.
Claims Coverage
The document includes two independent claims: one that specifies how to derive and set a fragile-bone-strength interventional threshold from a population data set using statistical correspondence to an osteoporosis BMD interventional threshold, and another that classifies a patient by comparing finite element–derived bone strength to a predetermined fragile-bone-strength interventional threshold.
Finite element–derived bone strength paired with BMD for threshold specification
Deriving, using a finite element analysis, a bone strength value for the bone strength parameter for each subject; receiving a BMD value for each subject; pairing, for each particular subject, the bone strength value and the BMD value to produce a set of paired measurements; and specifying the value for the bone strength interventional threshold responsive to an established BMD interventional threshold value for osteoporosis and a statistical correspondence of the set of paired measurements.
Patient classification by comparing finite element–derived bone strength to a predetermined fragile-bone-strength threshold
Deriving, using a finite element analysis, a bone strength value of a bone strength parameter for a bone portion of the patient; receiving a predetermined interventional threshold value for the fragile-bone-strength condition for said bone strength parameter; and classifying the patient for the fragile-bone-strength condition by producing a fragile-bone-strength classification responsive to a processor-implemented comparison of said bone strength value and said predetermined interventional threshold value.
Overall, claim coverage focuses on specifying a fragile-bone-strength interventional threshold by pairing finite element analysis-derived bone strength with BMD and aligning the result to an established osteoporosis BMD interventional threshold via statistical correspondence, and on classifying a patient by comparing a finite element–derived bone strength value for the patient to the predetermined fragile-bone-strength interventional threshold.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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