Sulfamate derivative compounds for use in treating or alleviating pain
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Publication Number
US-9834535-B2
Publication Date
2017-12-05
Expiration Date
Abstract
The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain; and a use of the sulfamate derivative compound or the pharmaceutically acceptable salt thereof in treating and/or alleviating pain, are provided.
Core Innovation
The disclosed invention relates to treating or alleviating pain in a subject in need thereof by administering a pharmaceutically effective amount of a pharmaceutical composition. The pharmaceutical composition comprises, as an active ingredient, a sulfamate derivative compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof. The sulfamate derivative is defined by substituent groups R1 through R9 and by integers n and m.
Chemical Formula 1 defines R1 and R2 as independently selected from hydrogen, C1–C5 alkyl, C2–C5 alkenyl, and C6–C10 aryl groups, including options where R1 and R2 together form a C3–C12 cycloalkyl group or a carbonyl group with the oxygen atom to which they attach. R3 through R7 are selected from groups including hydroxyl, alkoxy, alkyl, alkenyl, aryl, alkoxycarbonyl, carboxyl, acyl, alkylthio, cyano, nitro, amine, alkylamine, and halogen, and R8 and R9 are hydrogen or C1–C3 alkyl.
The disclosed compound family includes stereochemically defined sulfamate derivatives featuring dioxolane, dioxaspiro[4,4], and dioxaspiro[4,5] ring systems, together with substituted phenyl groups such as 2-chlorophenyl, 2-fluorophenyl, iodophenyl, 2-methylphenyl, 2-aminophenyl, and 2-phenyl. The examples and preparation content report title compounds, stereochemical forms, and ^1H NMR chemical shifts, and include related sodium sulfonyl/methoxy-sulfonyl amide forms.
Claims Coverage
The independent claim covers a method of treating or alleviating pain by administering a pharmaceutically effective amount of a sulfamate-derivative pharmaceutical composition, with the active ingredient defined by Chemical Formula 1 or a pharmaceutically acceptable salt thereof. The claim set includes 1 independent claim, with dependent claims refining pain categories, stereochemical forms, explicitly listed active-compound variants, and integer constraints for m and n.
Pain treatment by Chemical Formula 1 sulfamate derivative
A method of treating or alleviating pain in a subject in need thereof by administering a pharmaceutically effective amount of a pharmaceutical composition comprising a sulfamate derivative compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient, with substituent definitions for R1 through R9 and structural parameters n and m.
Pain category limitation to nociceptive, psychogenic, inflammatory, and pathological pain
The method further selects the pain as one or more of nociceptive pain, psychogenic pain, inflammatory pain, and pathological pain.
Pain category limitation to neuropathic and related pain types
The method further selects the pain as one or more of neuropathic pain, cancer pain, postoperative pain, trigeminal neuralgia pain, idiopathic pain, diabetic neuropathic pain, and migraine.
Stereochemical form limitation for the active compound
The method uses the compound in the form of a racemate, an enantiomer, a diastereomer, a mixture of enantiomers, or a mixture of diastereomers.
Explicit stereoisomeric sulfamate and sodium sulfonyl/methoxy-sulfonyl amide variants
The method uses a compound selected from explicitly listed stereoisomeric sulfamates and related sodium sulfonyl/methoxy-sulfonyl amide forms, including specified stereochemically defined dioxolan-4-yl sulfamate variants and corresponding sodium derivatives.
Integer range limitation for m and n
The method further defines m and n as integers independently in the range 0 to 2.
Overall, the claim coverage centers on administering a pharmaceutically effective amount of a Chemical Formula 1 sulfamate-derivative pharmaceutical composition for pain treatment, with dependent claims narrowing the pain types, restricting stereochemical forms, specifying an explicit list of stereoisomeric sulfamate and sodium sulfonyl/methoxy-sulfonyl amide variants, and constraining m and n within a defined integer range.
Stated Advantages
Treating or alleviating pain in a subject in need thereof.
Documented Applications
A method for treating or alleviating pain in a subject in need thereof.
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