Compositions and methods of improving cognitive performance
Inventors
Bickford, Paula C. • Sanberg, Cyndy Davis • Tan, Jun • Shytle, Roland Douglas • Sanberg, Paul D.
Assignees
University of South Florida • Natura Therapeutics Inc • Office of General Counsel of VA • University of South Florida St Petersburg
Publication Number
US-9827285-B1
Publication Date
2017-11-28
Expiration Date
2034-05-30
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Abstract
Provided herein are compositions, formulations, kits, and methods for improving or modifying cognitive performance in an individual having normal-age related cognitive decline. The composition can include an amount of a blueberry extract, L-carnosine, a green tea extract, vitamin D3, and a grape extract. The composition can be included in a pharmaceutical formulation and be administered to a subject having normal-age related cognitive decline according to a dosing regimen.
Core Innovation
The invention provides compositions, formulations, kits, and methods for improving or modifying cognitive performance in individuals experiencing normal age-related cognitive decline. The core formulation comprises a combination of blueberry extract, L-carnosine, green tea extract, vitamin D3, and grape extract, which can be administered in various pharmaceutical forms and according to specific dosing regimens.
The problem addressed is the widespread occurrence of normal age-related cognitive decline, which begins as early as age 25 and affects cognitive speed, memory, attention, and overall intellectual achievement. Age-related neuroanatomical and biological changes, including inflammation, oxidative stress, and hormonal decline, contribute to this deterioration and negatively impact quality of life, productivity, and job performance.
The disclosed compositions aim to treat, prevent, or delay normal age-related cognitive decline by delivering specified amounts of the active ingredients, with optional inclusion of a pharmaceutically acceptable carrier or excipient. The methods describe dosing strategies and administration forms, and demonstrate efficacy in improving cognitive performance as measured by standard cognitive assessment tests in subjects with normal cognitive aging.
Claims Coverage
There is one independent claim outlining the inventive features.
Method of treating cognitive decline using specific composition
The method comprises administering to a subject in need thereof a dosage form containing: - About 350 mg to about 25 g of blueberry extract - About 10 mg to about 200 mg of L-carnosine - About 350 mg to about 25 g of green tea extract - About 50 IU to about 4000 IU of vitamin D3 - About 1 mg to about 60 mg of grape extract The administration is for the purpose of treating cognitive decline.
The claim coverage is centered on a method for treating cognitive decline by administering a defined combination of blueberry extract, L-carnosine, green tea extract, vitamin D3, and grape extract within specified dosage ranges.
Stated Advantages
The composition improves cognitive performance in individuals with normal age-related cognitive decline, as measured by cognitive assessment tests.
Administration of the composition results in improvements in processing speed, which is a domain typically affected by normal cognitive aging.
The composition is well tolerated by older adult participants, with no significant differences in adverse events compared to placebo.
Improvements were observed with relatively short administration time (2 months), which is shorter than other studies on similar interventions.
Documented Applications
Treating, preventing, or delaying normal age-related cognitive decline in humans.
Improving cognitive performance in subjects with normal age-related cognitive decline.
Modifying cognitive performance in individuals suffering from abnormal cognitive decline, including mild cognitive impairment, Parkinson's disease, Alzheimer's disease, or dementia.
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