Methods and devices for remote ischemic conditioning via partial limb occlusion
Inventors
Assignees
INFARCT REDUCTION TECHNOLOGIES Inc • Lifecuff Technologies Inc
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Publication Number
US-9801780-B2
Publication Date
2017-10-31
Expiration Date
Abstract
Single- or dual-bladder devices for automated delivery of remote ischemic conditioning treatment via partial limb occlusion involve various methods of operating the cuff in which partial or full limb occlusion is achieved during the periods of cuff inflation. Achieving clinical benefits of remote ischemic conditioning without extended cessation of limb blood flow are advantageous due to lower required cuff pressure and reduced risk of clot formation in the limb vasculature.
Core Innovation
The disclosed invention relates to a device for delivery of remote ischemic conditioning treatment to a subject. The device includes a cuff configured for placement over a limb and a controller operably connected to the cuff. Upon activation, the controller delivers remote ischemic conditioning by performing a plurality of remote ischemic conditioning treatment cycles that include cuff inflation and cuff deflation periods.
During each treatment cycle, the controller causes cuff inflation to a pressure sufficient to cause at least a partial reduction of blood flow in the limb and to produce ischemic stress for at least about one minute. The controller then causes cuff deflation to increase blood flow in the limb and relieve the ischemic stress. The device is configured to avoid complete occlusion of the limb by the cuff lasting more than about one minute during at least one of the treatment cycles.
In certain implementations, the controller varies cuff pressure during at least one period of cuff inflation, including on a predetermined schedule, to increase or decrease ischemic stress. The pressure variation can alternate between partial occlusion and complete occlusion of blood flow during at least one treatment cycle. In further implementations, the ischemic stress is based on reaching or exceeding a predetermined ischemic stress threshold, including a blood flow reduction threshold or a cumulative limb oxygenation reduction threshold.
Claims Coverage
The partial content identifies three independent claims that share the same remote ischemic conditioning delivery structure, with inventive features centered on cycle-based inflation and deflation, avoidance of prolonged complete occlusion, ischemic-stress threshold definition, and pressure modulation.
Inflation/deflation remote ischemic conditioning cycles with ischemic stress duration
A device with a cuff over a limb and a controller configured to deliver remote ischemic conditioning treatment by performing a plurality of remote ischemic conditioning treatment cycles, each cycle including a cuff inflation period maintaining at or above a pressure sufficient to cause at least a partial reduction of blood flow to produce ischemic stress for at least about one minute, and a cuff deflation period to increase blood flow and relieve the ischemic stress.
Avoiding prolonged complete occlusion during at least one treatment cycle
The device is configured to avoid complete occlusion of the limb by the cuff lasting more than about one minute during at least one of the treatment cycles.
Varying pressure during an inflation period to increase or decrease ischemic stress
During at least one inflation period, the controller varies pressure in the cuff so as to increase or decrease ischemic stress in the limb.
Reaching or exceeding a predetermined ischemic stress threshold
A controller configured so that the cuff inflation period reaches or exceeds a predetermined ischemic stress threshold while producing an ischemic stress in the limb, with the cuff inflation period lasting at least about one minute and followed by a cuff deflation period to relieve the ischemic stress.
Predetermined schedule alternation between partial occlusion and complete occlusion
On a predetermined schedule, the controller varies cuff pressure during at least one period of cuff inflation to alternate between partial occlusion and complete occlusion of the blood flow in the limb during at least one of the treatment cycles.
Across the independent claims, coverage centers on a cuff-and-controller system that performs multiple remote ischemic conditioning treatment cycles with cuff inflation for at least about one minute to generate ischemic stress and cuff deflation to relieve that stress, while avoiding complete occlusion by the cuff lasting more than about one minute. Additional claim coverage specifies a predetermined ischemic stress threshold and controller pressure modulation during inflation, including scheduled alternation between partial and complete occlusion.
Stated Advantages
Avoids complete occlusion of the limb by the cuff lasting more than about one minute during at least one treatment cycle.
Documented Applications
No documented applications found
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