Composition for tissue/cell repair
Inventors
Assignees
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Publication Number
US-9782458-B2
Publication Date
2017-10-10
Expiration Date
Abstract
The composition for tissue/cell repair facilitates healing of damaged tissues, promoting tissue and cell growth, protecting cells and tissues, and reducing scar tissue. The composition includes hydrolyzed collagen, and may include high molecular weight hydrolyzed collagen. The hydrolyzed collagen may be combined with native collagen and/or at least one other therapeutic agent. For example, the therapeutic agent may be a polysulfated glycosaminoglycan, a glucosamine salt, or mixtures thereof. The collagen may be derived from two or more different sources, and may be combined with hydrolyzed whey and/or elastin.
Core Innovation
The described invention provides a tissue/cell repair and wound-healing composition centered on hydrolyzed collagen, optionally including high molecular weight (HMW) hydrolyzed collagen. The composition may further include hydrolyzed whey protein and may also include native collagen, with collagen sources identified as bovine, porcine, marine, or synthetic.
The disclosure characterizes hydrolyzed collagen and HMW hydrolyzed collagen by molecular-weight ranges and explains comparative functional behavior, including faster/longer bacteriostasis, improved occlusion, reduced dressing changes, and accelerated epithelialization/cellular repair. It further describes the option to combine collagen-based components with other therapeutic ingredients, including polysulfated glycosaminoglycans such as chondroitin sulfate and glucosamine salts.
The disclosure provides example formulations and ratios tailored to wet versus dry wounds, including component proportions involving collagen and additional materials such as whey and elastin. It also discloses multiple delivery forms for administration, including powder, gel, film, and injectable/oral formats, each described with functional attributes such as conforming or absorbing exudate or moisture and bacteriostatic properties.
Claims Coverage
The partial set contains two independent claims: clm-00001 (a method of treating a wound) and clm-00002 (a composition for promoting wound healing). Across the independent claims, the inventive coverage is defined by specific weight-percentage ranges for marine sourced collagen, hydrolyzed whey protein, and bovine sourced collagen, together with at least one additional ingredient selected from a defined list.
Marine collagen with defined weight range
About 20% to about 30% by weight marine sourced collagen.
Hydrolyzed whey protein with defined weight range
About 30% by weight hydrolyzed whey protein.
Bovine collagen with defined weight range
About 50% to about 60% by weight bovine sourced collagen.
Adjunct wound-treatment ingredient selected from a defined list
At least one of a glycosaminoglycan, zinc, an alginate, cellulose, antibiotic, honey, and glutamine.
The independent claims focus on a wound-healing method or wound-healing composition that combines specified weight-percentage ranges of marine sourced collagen, hydrolyzed whey protein, and bovine sourced collagen, together with at least one additional ingredient selected from glycosaminoglycan, zinc, alginate, cellulose, antibiotic, honey, or glutamine.
Stated Advantages
Faster/longer bacteriostasis.
Improved occlusion.
Reduced dressing changes.
Accelerated epithelialization/cellular repair.
Documented Applications
Treating wounds by administering the disclosed collagen/whey-based composition to a wound.
Promoting wound healing using the disclosed composition.
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