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Publication Number
US-9737308-B2
Publication Date
2017-08-22
Expiration Date
Abstract
An implant can include a support component, a cover component, and a valve component. The valve component can be operable to permit flow through the implant. The implant can be delivered on a catheter, with one of the ends of the implant being selectively expanded to permit temporary occlusion of a vessel while delivering a material through the valve component to a downstream target region. The other end of the implant can thereafter be released such that the implant occludes the vessel, or the implant can be removed from the vessel entirely.
Core Innovation
The invention relates to a catheter-assisted material delivery device for use in a body lumen. The device includes an implant having an expandable support member and an outflow end that defines an aperture at a distalmost loop. In a collapsed configuration the expandable support is configured to be delivered via a catheter, and in an expanded configuration the support is configured for placement in a body lumen for treatment of a tumor or material treatment target region.
A cover component extends along the expandable support member and defines an aperture at the distalmost loop at the outflow end. A valve component permits controlled material delivery and restricts backflow. The valve component includes nonmovable and movable components, where the movable component moves between an open position that permits outflow of material through a gap extending about an entire periphery of the movable component, and a closed position in which the movable component abuts the nonmovable component to close the gap and restrict backflow of the material into the aperture.
In an expanded configuration, the implant is configured for temporary vessel occlusion while material is delivered to a downstream target region. The expandable support and valve functionality enable material delivery such as embolization of tumors, drug/contrast delivery, and radioembolization particles, while restricting backflow into the aperture. After material delivery, the remaining implant can occlude the vessel, or the implant can be removed to restore flow.
Claims Coverage
The relevant independent claims cover expandable material delivery device configurations. Each includes an expandable support member formed by paired wires into a series of loops with a distalmost loop, and a valve function with open and closed positions that control outflow and restrict backflow through a defined opening or aperture using gaps about an entire periphery of a movable component.
Expandable wire-loop support with distalmost loop and outflow aperture
An expandable support member comprising a pair of wires collectively forming a series of loops configured to expand from a collapsed configuration to an expanded configuration for placement in a body lumen, the support member comprising a lumen and an outflow end, and including a distalmost loop for defining an opening therethrough.
Cover component defining an aperture at the distalmost loop
A cover component extending along the support member and defining an aperture at a distalmost loop at the outflow end of the support member.
Movable and nonmovable valve components switching between open and closed positions
A valve component comprising nonmovable and movable components, the nonmovable component coupled to the distalmost loop and the movable component coupled to the nonmovable component via a plurality of fasteners about an entire periphery to move between an open position permitting outflow of a material through the aperture via a gap extending about an entire periphery, and a closed position in which the movable component abuts the nonmovable component to close the gap and restrict backflow of the material into the aperture.
Valve components with through opening and peripheral edge coupling
A valve component attached to the distalmost loop, the valve component comprising a movable component and a nonmovable component, the nonmovable component comprising a through opening and a peripheral edge, the nonmovable component coupled along an entirety of the peripheral edge to a perimeter of the distalmost loop, and the movable component coupled to the nonmovable component via a plurality of fasteners about the entire peripheral edge to move between an open position permitting outflow through the opening via a gap about an entire periphery and a closed position positioning against the nonmovable component to cover the through opening.
Separate valve component from the cover component
A valve component comprising a material separate from the cover component and comprising nonmovable and movable components, the nonmovable component coupled to and movable relative to the distalmost loop, and the movable component coupled to the nonmovable component via a plurality of fasteners about an entire periphery to permit movement between an open position allowing outflow through the opening via a gap about an entire periphery and a closed position closing the gap and restricting backflow into the opening.
Across the independent claims, the core inventive structure is an expandable wire-loop support with a distalmost loop and an aperture or opening, combined with a valve that uses movable and nonmovable components and peripheral fastener coupling to switch between an open position that permits outflow through a circumferential gap and a closed position that seats against the nonmovable component to close the gap and restrict backflow.
Stated Advantages
Restricting backflow of the material into the aperture or opening via a closed position.
Permitting outflow of a material through an aperture or opening via an open position through a gap extending about an entire periphery.
Enabling temporary vessel occlusion while delivering material to a downstream target region.
Allowing restoration of blood flow by removal of the implant after material delivery.
Documented Applications
Catheter-assisted endovascular treatment including embolization of tumors.
Drug or contrast delivery.
Radioembolization particles delivery.
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