Method of treating inflammation
Inventors
Chan, Phillip P. • Young, Wei-Tai • Capponi, Vincent J. • Golobish, Thomas D. • Bartlett, Robert H. • Ali, Humayra Begum
Assignees
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Publication Number
US-9717755-B2
Publication Date
2017-08-01
Expiration Date
Abstract
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Core Innovation
The invention relates to treating systemic, regional, or local inflammation in a patient suffering inflammation by administering a therapeutically effective dose of a sorbent for an inflammatory mediator. The sorbent binds inflammatory mediators, wherein the inflammatory mediator comprises cytokines, and the approach is directed to inflammation contexts including systemic inflammatory response syndrome and sepsis.
The sorbent comprises a biocompatible polymer that includes a cross-linked, porous styrene or divinylbenzene copolymer. The biocompatible polymer has a pore structure such that the total pore volume of pore size in the range of 50 Å to 3000 Å is greater than 0.5 cc/g to 3.0 cc/g dry polymer.
The disclosed embodiments further include administration routes such as oral, feeding tube, peritoneal, and rectal. The polymer materials are described as non-metabolizable by humans and animals, and the polymer may be supplied as a dry powder or dry particulate that can be wetted in the alimentary canal. Additional disclosed refinements include coated or hydrophilic self-wetting polymer and ion exchange polymer.
Claims Coverage
The independent claim covers a method of treating systemic, regional, or local inflammation by administering a therapeutically effective dose of a cytokine sorbent based on a biocompatible, cross-linked, porous styrene or divinylbenzene copolymer with specified pore-volume constraints. The inventive scope is primarily defined by three inventive features, with dependent claims adding refinements.
Treating inflammation with a cytokine sorbent dose
A method of treating systemic, regional, or local inflammation from a patient suffering inflammation, comprising administration of a therapeutically effective dose of a sorbent for an inflammatory mediator in said patient, wherein said inflammatory mediator comprises cytokines.
Cross-linked porous styrene or divinylbenzene copolymer sorbent
The sorbent is a biocompatible polymer that comprises a cross-linked, porous styrene or divinylbenzene copolymer.
Porous polymer pore-volume constraint (50 Å to 3000 Å)
The biocompatible polymer has a pore structure such that the total pore volume of pore size in the range of 50 Å to 3000 Å is greater than 0.5 cc/g to 3.0 cc/g dry polymer.
Overall, the claim coverage centers on administering a therapeutically effective cytokine-binding sorbent for systemic, regional, or local inflammation, where the sorbent is a biocompatible cross-linked porous styrene or divinylbenzene copolymer with a specified total pore volume across 50 Å to 3000 Å.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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