Method and apparatus for determining effects of transcranial magnetic stimulation to a brain
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Publication Number
US-9696387-B2
Publication Date
2017-07-04
Expiration Date
Abstract
The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.
Core Innovation
The invention relates to computer implemented determination of one or more cumulative effects of an application of navigated transcranial magnetic stimulation to at least one location in a brain. A three dimensional area of a stimulation dose induced by a navigated transcranial magnetic stimulation pulse from a coil device is determined for the location, and a growth function of the stimulation dose is determined in the location, where the growth function is derived at least partially according to a known, inferred or estimated tissue type of the location.
A decay function of the stimulation dose is determined in the location, where the decay function is at least partially derived from a period of elapsed time after the stimulation dose. A cumulative stimulation dose for the location is then calculated based on the growth function and the decay function at one or more points in time, and the navigated transcranial magnetic stimulation is administered to the brain based at least partially on the calculated cumulative stimulation dose.
Further aspects include deriving the growth function and the decay function, and calculating the cumulative stimulation dose at one or more points in time for the at least one location, for the purpose of administering navigated transcranial magnetic stimulation based on the calculated cumulative stimulation dose. The document also describes representing or approximating determined or approximated one or more effects to a user using a non-transitory computer readable medium.
Claims Coverage
The document includes three independent claims. Across them, the core claim coverage centers on tissue-informed growth, time-based decay, cumulative stimulation dose calculation at one or more points in time, and administration of navigated transcranial magnetic stimulation based at least partially on the calculated cumulative stimulation dose.
Three dimensional stimulation-dose area with tissue-derived growth and time-derived decay for cumulative stimulation dose administration
Determining a three dimensional area of a stimulation dose induced by a navigated transcranial magnetic stimulation pulse from a coil device; determining a growth function derived at least partially according to a known, inferred or estimated tissue type of the location; determining a decay function derived at least partially from a period of elapsed time after the stimulation dose; calculating a cumulative stimulation dose based on the growth function and the decay function at one or more points in time; administering the navigated transcranial magnetic stimulation based at least partially on the calculated cumulative stimulation dose.
Growth function and decay function for cumulative stimulation dose calculation and dose-based administration
Determining a growth function derived at least partially according to a known, inferred or estimated tissue type of the location; determining a decay function derived at least partially from a period of elapsed time after the stimulation dose; calculating a cumulative stimulation dose based on the growth function and the decay function at one or more points in time; administering the navigated transcranial magnetic stimulation based at least partially on the calculated cumulative stimulation dose.
Non-transitory medium representing determined or approximated effects for nTMS based on growth and decay
Providing to a user a determined or approximated one or more effects of application of a navigated transcranial magnetic stimulation to a brain; determining a growth function derived at least partially according to a known, inferred or estimated tissue type; determining a decay function derived at least partially from a period of elapsed time after the stimulation dose; calculating a cumulative stimulation dose based on the growth function and the decay function at one or more points in time; administering the navigated transcranial magnetic stimulation based at least partially on the calculated cumulative stimulation dose.
The independent claims collectively define a framework in which tissue type informs a stimulation dose growth function, elapsed time informs a stimulation dose decay function, and the combination yields a cumulative stimulation dose used to administer navigated transcranial magnetic stimulation; one independent claim additionally includes determining a three dimensional stimulation-dose area from the coil pulse, and another independent claim covers a non-transitory computer readable medium for representing determined or approximated effects.
Stated Advantages
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