In-situ cross-linkable polymeric compositions and methods thereof
Inventors
Assignees
Publication Number
US-9687584-B1
Publication Date
2017-06-27
Expiration Date
2032-11-12
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Abstract
A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.
Core Innovation
The invention discloses a biocompatible polymeric composition designed to form a gelatinous, in-situ cross-linkable matrix for wound healing and hemostasis. The composition comprises one or more polyanionic polymers, such as alginates or hyaluronates, and one or more polycationic polymers, such as chitosan or DEAE-Dextran, that together enable solidification and rapid clotting at the wound site. A cross-linking agent, such as aqueous calcium chloride, may further be included to enhance matrix stability.
This polymeric composition can be tailored for varying viscosity and structural properties by adjusting the ratio of the polymeric components, allowing for flexibility in application depending on wound type or anatomical site. The system supports the integration of drug formulations for combined wound healing and therapeutic delivery. It can be applied as a mixture, in sequence, or simultaneously, to both internal and external wounds.
The problem addressed by this invention is the difficulty in treating acute and chronic wounds, which include delayed healing, persistent inflammation, possible infection, reduced granulation, and increased pain. Existing dressings often do not provide adequate fibrous protective films or hemostatic efficacy, and can require additional procedures like debridement. The invention aims to overcome these issues by providing a composition that is easily applied, forms a stable matrix with anti-microbial properties, and promotes accelerated tissue regeneration and blood clotting without the need for pressure.
Claims Coverage
There is one independent claim defining the main inventive feature of the patent.
Method of treating a bleed using a polymeric composition of sodium alginate and chitosan in water
A method involves applying to a bleed site a composition comprising: - About 0.1% to about 5% by weight of sodium alginate - About 2% to about 25% by weight of chitosan - The balance of the composition is water The method is intended for treating a bleed in a patient in need thereof.
The main inventive feature covers the use of a specific aqueous mixture of sodium alginate and chitosan for treating bleeds.
Stated Advantages
The composition allows for rapid achievement of hemostasis without the need to apply pressure.
The biocompatible polymeric composition forms a solidified matrix that enhances wound healing and tissue regeneration.
The formulation is easily applied and forms a stable, protective, and durable matrix at the wound site.
The system can be adjusted for various wound types, offering controllable viscosity and mechanical strength.
The composition can be integrated with therapeutic agents to provide additional functions such as antimicrobial activity or drug delivery.
Documented Applications
Treatment of external lacerations, abrasions, burns, and superficial cuts and scrapes.
Treatment of internal wounds, such as damage to parenchymal organs or lacerations in the gastrointestinal tract.
Control of arterial, venous, dental, or oral bleeds.
Provision of a wound healing matrix for tissue regeneration in humans, mammals, marine animals, and reptiles.
Application for rapidly achieving hemostasis in compromised blood vessels.
Use as a carrier for therapeutic agents, including antimicrobial agents, antibiotics, hormones, proteins, and iodine, for wound healing or antimicrobial purposes.
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